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Gene Expression Data
Assay Details
Assay
Reference: J:67864 Ohshima T, et al., Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2764-9
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6510521
Gene symbol: Itpr1
Gene name: inositol 1,4,5-trisphosphate receptor 1
Antibody: anti-P400 (clone 4C11)
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
Results
Specimen 4E: postnatal day 21; Cdk5r1tm1Ohsh/Cdk5r1tm1Ohsh (more )
Structure Level Pattern Image Note
TS28: cerebellum Present Regionally restricted 4E Authors report subtle disturbances of alignment of Purkinje cells.
Specimen 4F: postnatal day 21; Cdk5r1tm1Ohsh/Cdk5r1tm1Ohsh (more )
Structure Level Pattern Image Note
TS28: cerebellum granule cell layer Present Regionally restricted 4F Purkinje cells localized abnormally within granule cell layer extend dendrites into molecular layer.
TS28: cerebellum molecular layer Present Regionally restricted 4F Purkinje cells localized abnormally within granule cell layer extend dendrites into molecular layer.
Specimen 4G: postnatal day 21; Cdk5r1tm1Ohsh/Cdk5r1tm1Ohsh, Cdk5tm1Kul/Cdk5+ (more )
Structure Level Pattern Image Note
TS28: cerebellum Present Regionally restricted 4G Authors report extensive migration defects of Purkinje cells and granule cells.
Specimen 4H: postnatal day 21; Cdk5r1tm1Ohsh/Cdk5r1tm1Ohsh, Cdk5tm1Kul/Cdk5+ (more )
Structure Level Pattern Image Note
TS28: cerebellum granule cell layer Present Regionally restricted 4H Dendrites of abnormally localized Purkinje cells in granular layer occasionally do not extend to molecular layer. Instead, dendrites are tangled and irregular in shape.
TS28: cerebellum molecular layer Present Regionally restricted 4H Dendrites of abnormally localized Purkinje cells in granular layer occasionally do not extend to molecular layer. Instead, dendrites are tangled and irregular in shape.
Specimen p35-/- rl/+ not shown: postnatal day 21; Cdk5r1tm1Ohsh/Cdk5r1tm1Ohsh, Relnrl/Reln+ (more )
Structure Level Pattern Image Note
TS28: cerebellum Present Regionally restricted Authors report defects in migration of cerebellar cortical neurons.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
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