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Gene Expression Data
Assay Details
Assay
Reference: J:217439 Srinivasan RS, et al., The Prox1-Vegfr3 feedback loop maintains the identity and the number of lymphatic endothelial cell progenitors. Genes Dev. 2014 Oct 1;28(19):2175-87
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6507016
Gene symbol: Pdpn
Gene name: podoplanin
Antibody: Anti-Podoplanin (clone 8.1.1)
Detection system: Alexa Fluor 488
Results
Specimen 2D: embryonic day 11.5; Prox1tm5(GFP/cre)Gco/Prox1+ (more )
Note: Triple labeled: green - Pdpn; red - Prox1 (assay MGI:6507015); blue - Pecam1 (assay MGI:6507017).
Structure Level Pattern Image Note
TS19: lymphatic system Present 2D
Specimen 2E: embryonic day 11.5; Flt4tm1Ali/Flt4+, Prox1tm5(GFP/cre)Gco/Prox1+ (more )
Note: Triple labeled: green - Pdpn; red - Prox1 (assay MGI:6507015); blue - Pecam1 (assay MGI:6507017).
Structure Level Pattern Image Note
TS19: lymphatic system Weak Regionally restricted 2E Expression downregulated in few scattered endothelial cells outside cardinal vein.
Specimen 2G: embryonic day 13.5; Prox1tm5(GFP/cre)Gco/Prox1+ (more )
Note: Triple labeled: green - Pdpn; red - Prox1 (assay MGI:6507015); blue - DAPI.
Structure Level Pattern Image Note
TS21: lymph sac Present 2G
Specimen 2H: embryonic day 13.5; Flt4tm1Ali/Flt4+, Prox1tm5(GFP/cre)Gco/Prox1+ (more )
Note: Triple labeled: green - Pdpn; red - Prox1 (assay MGI:6507015); blue - DAPI.
Structure Level Pattern Image Note
TS21: lymph sac Trace 2H Level of expression drastically reduced
Specimen 2I: embryonic day 15.5; Prox1tm5(GFP/cre)Gco/Prox1+ (more )
Note: Triple labeled: green - Pdpn; red - Prox1 (assay MGI:6507015); blue - Pecam1 (assay MGI:6507017).
Structure Level Pattern Image Note
TS23: lymphatic system Present Regionally restricted 2I Authors report mostly normal-looking lymphatic vessels.
TS23: skin Present Regionally restricted 2I Authors report mostly normal-looking lymphatic vessels.
Specimen 2J: embryonic day 15.5; Flt4tm1Ali/Flt4+, Prox1tm5(GFP/cre)Gco/Prox1+ (more )
Note: Triple labeled: green - Pdpn; red - Prox1 (assay MGI:6507015); blue - Pecam1 (assay MGI:6507017).
Structure Level Pattern Image Note
TS23: lymphatic system Absent 2J No Pdpn expression in the few Prox1-expressing lymphatic vessels.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory