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Gene Expression Data
Assay Details
Assay
Reference: J:213694 Cantu C, et al., Pax6-dependent, but beta-catenin-independent, function of Bcl9 proteins in mouse lens development. Genes Dev. 2014 Sep 1;28(17):1879-84
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6506825
Gene symbol: Pax6
Gene name: paired box 6
Antibody: anti-Pax6
Detection system: Secondary antibody
Results
Specimen 4F WT: embryonic day 10.5 (more )
Note: Double labeled: magenta - Pax6; blue - DAPI.
Structure Level Pattern Image Note
TS17: head surface ectoderm Strong Regionally restricted 4F WT Head ectoderm forming lens pit expresses high levels of Pax6.
TS17: lens pit Present 4F WT Expression higher than in presumptive retina.
TS17: optic cup Weak 4F WT
Specimen 4F Pygo2-KO: embryonic day 10.5; Pygo2tm2Kba/Pygo2tm2Kba (more )
Note: Double labeled: magenta - Pax6; blue - DAPI.
Structure Level Pattern Image Note
TS17: head surface ectoderm Weak Regionally restricted 4F Pygo2-KO Reduced expression in surface head ectoderm.
TS17: optic cup Present 4F Pygo2-KO Stronger expression in presumptive retina.
Specimen 4F Bcl9/9l delta HD1: embryonic day 10.5; Bcl9tm1.1Kba/Bcl9tm1.1Kba, Bcl9ltm1.1Kba/Bcl9ltm1.1Kba (more )
Note: Double labeled: magenta - Pax6; blue - DAPI.
Structure Level Pattern Image Note
TS17: head surface ectoderm Weak Regionally restricted 4F Bcl9/9l-deltaHD1 Reduced expression in surface head ectoderm.
TS17: optic cup Present 4F Bcl9/9l-deltaHD1 Stronger expression in presumptive retina.
Specimen 4F Bcl9/9l delta HD1: embryonic day 10.5; Bcl9tm2.1Kba/Bcl9tm2.1Kba, Bcl9ltm2.1Kba/Bcl9ltm2.1Kba (more )
Note: Double labeled: magenta - Pax6; blue - DAPI.
Structure Level Pattern Image Note
TS17: lens pit Present 4F Bcl9/9l-deltaHD2 Expression comparable to wild-type.
TS17: optic cup Present 4F Bcl9/9l-deltaHD2
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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