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Gene Expression Data
Assay Details
Assay
Reference: J:240033 Lee B, et al., Identification of a conserved cis-regulatory element controlling mid-diencephalic expression of mouse Six3. Genesis. 2017 Mar;55(3)
Assay type: RNA in situ
MGI Accession ID: MGI:6505857
Gene symbol: Six3
Gene name: sine oculis-related homeobox 3
Probe: Six3 probe33
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 1A/2A: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: optic cup Present 1A , 2A Expression in eye field (optic vesicle).
TS17: forebrain Present Regionally restricted 2A , 1A Expression in ventral forebrain
TS17: diencephalon Present Regionally restricted 1A , 2A Expression in mid-diencephalic regions.
TS17: midbrain Present 1A , 2A
Specimen 2B: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: brain Present Regionally restricted 2B
Specimen 2C: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: midbrain Present Regionally restricted 2C
Specimen 2D: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: forebrain-midbrain boundary region Present Regionally restricted 2D
Specimen 2E: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: forebrain Present Regionally restricted 2E Expression in ventral forebrain
TS20: hypothalamus Present 2E
TS20: prethalamus Present 2E
TS20: midbrain Present 2E
Specimen 2F: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: midbrain Present 2F
Specimen 2G: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: prethalamus Present 2G
TS20: thalamus Present Regionally restricted 2G Expression in rostral thalamus
Specimen 4A: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: telencephalon Present 4A
Specimen 4B: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: telencephalon Present 4B
TS17: diencephalon Present Regionally restricted 4B Expression in the hypothalamus, prethalamus and thalamus
TS17: midbrain Present 4B
TS17: olfactory placode Present 4B
TS17: optic cup Present 4B
Specimen 4C: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: hypothalamus Present 4C
TS20: midbrain Present 4C
TS20: prethalamus Present 4C
TS20: thalamus Present 4C
TS20: forebrain-midbrain boundary region Present Regionally restricted 4C Expression in pretectum.
Specimen 4D: embryonic day 9.5; Ascl1tm1Reed/Ascl1tm1Reed (more )
Structure Level Pattern Image Note
TS15: telencephalon Present 4D
Specimen 4E: embryonic day 10.5; Ascl1tm1Reed/Ascl1tm1Reed (more )
Structure Level Pattern Image Note
TS17: diencephalon Present Regionally restricted 4E Expression similarly observed in hypothalamus, prethalamus and thalamus.
TS17: olfactory placode Present 4E
TS17: optic cup Present 4E
TS17: midbrain Present Regionally restricted 4E Dramatic loss of expression in the anterior midbrain. Expression in posterior midbrain similar to control.
Specimen 4F: embryonic day 12.5; Ascl1tm1Reed/Ascl1tm1Reed (more )
Structure Level Pattern Image Note
TS20: hypothalamus Present 4F Expression in hypothalamus, prethalamus and thalamus similar to control.
TS20: prethalamus Present 4F Expression in hypothalamus, prethalamus and thalamus similar to control.
TS20: thalamus Present 4F Expression in hypothalamus, prethalamus and thalamus similar to control.
TS20: midbrain Present Regionally restricted 4F Dramatic loss of expression in the anterior midbrain. Expression in posterior midbrain similar to control.
TS20: forebrain-midbrain boundary region Trace Regionally restricted 4F Dramatic loss of expression in pretectum
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory