About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:165470 Hallock PT, et al., Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L. Genes Dev. 2010 Nov 1;24(21):2451-61
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6502132
Gene symbol: Syn1
Gene name: synapsin I
Results
Specimen 7A Crkf/f; Crk-Lf/f: embryonic day 18.5; Crktm1Cur/Crktm1Cur, Crkltm1Cur/Crkltm1Cur (more )
Note: Also stained for Syn2 (assay MGI:6502134) and Syp (assay MGI:6502130); all green.
Structure Level Pattern Image Note
TS26: diaphragm Present Regionally restricted 7A Synaptophysin/Synapsin Crkf/f; Crk-Lf/f Expression at synapses.
Specimen 7A Crkf/f; Crk-Lf/f inset: embryonic day 18.5; Crktm1Cur/Crktm1Cur, Crkltm1Cur/Crkltm1Cur (more )
Note: Double labeled: green - Syn1, Syn2 and Syp (assay MGI:6502130); red - AchR.
Structure Level Pattern Image Note
TS26: diaphragm Present Regionally restricted 7A Synaptophysin/Synapsin Crkf/f; Crk-Lf/f inset Expression at synapses.
Specimen 7A Crkf/f; Crk-Lf/f; myf5cre: embryonic day 18.5; Crktm1Cur/Crktm1Cur, Crkltm1Cur/Crkltm1Cur, Myf5tm3(cre)Sor/Myf5+ (more )
Note: Conditional mutant. Also stained for Syn2 (assay MGI:6502134) and Syp (assay MGI:6502130); all green.
Structure Level Pattern Image Note
TS26: diaphragm Present Regionally restricted 7A Synaptophysin/Synapsin Crkf/f; Crk-Lf/f; myf5cre Authors report fewer synapses than wild type, with synapses broadly distributed in muscle.
Specimen 7A Crkf/f; Crk-Lf/f; myf5cre inset: embryonic day 18.5; Crktm1Cur/Crktm1Cur, Crkltm1Cur/Crkltm1Cur, Myf5tm3(cre)Sor/Myf5+ (more )
Note: Conditional mutant. Double labeled: green - Syn1, Syn2 and Syp (assay MGI:6502130); red - AchR.
Structure Level Pattern Image Note
TS26: diaphragm Present Regionally restricted 7A Synaptophysin/Synapsin Crkf/f; Crk-Lf/f; myf5cre inset Authors report fewer synapses than wild type.
Specimen 8A Crkf/f; Crk-Lf/f: embryonic day 18.5; Crktm1Cur/Crktm1Cur, Crkltm1Cur/Crkltm1Cur (more )
Structure Level Pattern Image Note
TS26: diaphragm Present Regionally restricted 8A Synapsin Crkf/f; Crk-Lf/f
Specimen 8A Crkf/f; Crk-Lf/f; myf5cre: embryonic day 18.5; Crktm1Cur/Crktm1Cur, Crkltm1Cur/Crkltm1Cur, Myf5tm3(cre)Sor/Myf5+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: diaphragm Present Regionally restricted 8A Synapsin Crkf/f; Crk-Lf/f; myf5cre Authors report synapses were unusually small.
Specimen 8C Crkf/f; Crk-Lf/f: embryonic day 18.5; Crktm1Cur/Crktm1Cur, Crkltm1Cur/Crkltm1Cur (more )
Structure Level Pattern Image Note
TS26: diaphragm Present Regionally restricted 8C Crkf/f: Crk-Lf/f
Specimen 8C Crkf/f; Crk-Lf/f; myf5cre: embryonic day 18.5; Crktm1Cur/Crktm1Cur, Crkltm1Cur/Crkltm1Cur, Myf5tm3(cre)Sor/Myf5+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: diaphragm Present Regionally restricted 8C Crkf/f; Crk-Lf/f; myf5cre Motor axons failed to terminate at synapses.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory