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Gene Expression Data
Assay Details
Assay
Reference: J:162778 Yang Z, et al., The mouse forkhead gene Foxp2 modulates expression of the lung genes. Life Sci. 2010 Jul 3;87(1-2):17-25
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6489993
Gene symbol: Foxp2
Gene name: forkhead box P2
Antibody: anti-Foxp2 A-3-3
Detection system: Secondary antibody coupled to horseradish peroxidase
Results
Specimen 2A: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: lung epithelium Present 2A
Specimen 2B: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: lobar bronchus epithelium Present 2B
Specimen 2C: embryonic day 12.5 (more )
Note: Stage of bronchial elongation.
Structure Level Pattern Image Note
TS20: lobar bronchus epithelium Strong Graded 2C Expression is strong in the elongating distal part of the bronchial epithelium and is weak in the proximal part.
Specimen 2D: embryonic day 13.5 (more )
Note: Stage of bronchial elongation.
Structure Level Pattern Image Note
TS21: lobar bronchus epithelium Strong Graded 2D' , 2D Expression is strong in the elongating distal part of the bronchial epithelium and is weak in the proximal part.
Specimen 2E: embryonic day 14.5 (more )
Note: Stage of bronchial elongation.
Structure Level Pattern Image Note
TS22: bronchiole epithelium Strong Graded 2E' , 2E Expression is strong in the elongating distal part of the bronchial epithelium and is weak in the proximal part.
Specimen 2F: embryonic day 15.5 (more )
Note: Stage of bronchiolar branching.
Structure Level Pattern Image Note
TS23: bronchiole epithelium Strong Regionally restricted 2F , 2F' Expression is in the newly elongating distal epithelium and is absent in the proximal bronchial epithelium.
Specimen 2G: embryonic day 16.5 (more )
Note: Stage of bronchiolar branching.
Structure Level Pattern Image Note
TS24: bronchiole epithelium Strong Regionally restricted 2G Expression is in the newly elongating distal epithelium and is absent in the proximal bronchial epithelium.
TS24: alveolus epithelium Strong 2G
Specimen 2H: embryonic day 17.5 (more )
Note: Saccular-alveolar stage.
Structure Level Pattern Image Note
TS25: bronchiole epithelium Present Regionally restricted 2H Expression is in the distal bronchiolar epithelium.
TS25: alveolus epithelium Present 2H
Specimen 2I: embryonic day 18.5 (more )
Note: Saccular-alveolar stage.
Structure Level Pattern Image Note
TS26: bronchiole epithelium Present Regionally restricted 2I Expression is in the distal bronchiolar epithelium.
TS26: alveolus epithelium Present 2I
Specimen 2J: postnatal adult (more )
Note: Double labeled: brown - Foxp2; blue - Acta2 (assay MGI:6490001).
Structure Level Pattern Image Note
TS28: lung alveolus Present 2J
TS28: respiratory bronchiole epithelium Absent 2J
TS28: terminal bronchiole epithelium Absent 2J
Specimen 2K: postnatal adult (more )
Note: Double labeled: brown - Foxp2; blue - Acta2 (assay MGI:6490001).
Structure Level Pattern Image Note
TS28: lung alveolus Present 2K
TS28: respiratory bronchiole epithelium Absent 2K
TS28: terminal bronchiole epithelium Absent 2K
Specimen 2M: postnatal adult (more )
Structure Level Pattern Image Note
TS28: lung alveolus Present Regionally restricted 2M Expression is in large cuboidal alveolar cells (type II cells).
Specimen 5A: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: lobar bronchus epithelium Present 5C , 5A
Specimen 5D: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: lobar bronchus epithelium Present 5F , 5D
Specimen 5G: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: lobar bronchus epithelium Present 5G , 5I
Specimen 5J: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: bronchiole epithelium Present 5J , 5L
Specimen 5M: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: bronchiole epithelium Present 5O , 5M
Specimen 6A: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: lobar bronchus epithelium Present Graded 6A Expression is strong in the newly branched bronchial epithelium and is weak in the old branched bronchial epithelium.
Specimen 6B: embryonic day 13.5; Foxf2tm1Miu/Foxf2tm1Miu (more )
Structure Level Pattern Image Note
TS21: lobar bronchus epithelium Present Graded 6B Expression in this mutant is the same as in wild-type.
Specimen 6C: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: bronchiole epithelium Present Graded 6C Expression is strong in the newly branched bronchial epithelium and is weak in the old branched bronchial epithelium.
Specimen 6D: embryonic day 14.5; Foxf2tm1Miu/Foxf2tm1Miu (more )
Structure Level Pattern Image Note
TS22: bronchiole epithelium Present Graded 6D Expression in this mutant is the same as in wild-type.
Specimen not shown: embryonic day 9.5; Foxf2tm1Miu/Foxf2tm1Miu (more )
Structure Level Pattern Image Note
TS15: lung Absent
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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