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Gene Expression Data
Assay Details
Assay
Reference: J:89365 Cecconi F, et al., Apaf1-dependent programmed cell death is required for inner ear morphogenesis and growth. Development. 2004 May;131(9):2125-35
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6489897
Gene symbol: Apaf1
Gene name: apoptotic peptidase activating factor 1
Reporter: lacZ
Direct Detection
Results
Specimen 1A: embryonic day 9.5; Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1+ (more )
Structure Level Pattern Image Note
TS15: otocyst Weak Widespread 1A Weak expression all through otic vesicle.
TS15: otocyst mesenchyme Present Regionally restricted 1A Expression in periotic mesenchyme developing into otic capsule.
Specimen 1B: embryonic day 10.5; Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1+ (more )
Structure Level Pattern Image Note
TS17: otocyst Weak Widespread 1B Weak expression all through otic vesicle.
TS17: otocyst mesenchyme Present Regionally restricted 1B Expression in periotic mesenchyme developing into otic capsule.
Specimen 1D: embryonic day 12.5; Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1+ (more )
Structure Level Pattern Image Note
TS20: endolymphatic appendage epithelium Strong Regionally restricted 1D Highest levels of expression in endolymphatic duct epithelium.
TS20: inner ear epithelium Present Regionally restricted 1D Expression slightly elevated in tips of semicircular ducts and in cochlear duct compared with rest of otic epithelium.
TS20: inner ear mesenchyme Present Regionally restricted 1D Expression in periotic mesenchyme.
Specimen 1E: embryonic day 12.5; Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1+ (more )
Structure Level Pattern Image Note
TS20: inner ear epithelium Present Regionally restricted 1E Expression in otic epithelium and surrounding mesenchyme.
TS20: inner ear mesenchyme Present Regionally restricted 1E Expression in otic epithelium and surrounding mesenchyme.
Specimen 1F: embryonic day 10.5; Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1+ (more )
Structure Level Pattern Image Note
TS17: embryo Present Widespread 1L
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory