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Gene Expression Data
Assay Details
Assay
Reference: J:91011 Kurokawa D, et al., Regulation of Otx2 expression and its functions in mouse forebrain and midbrain. Development. 2004 Jul;131(14):3319-31
Assay type: RNA in situ
MGI Accession ID: MGI:6479848
Gene symbol: Otx2
Gene name: orthodenticle homeobox 2
Probe: Otx2 probeA
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 1Bk: embryonic day 10.5 (more )
Note: frontal view
Structure Level Pattern Image Note
TS17: diencephalon Present 1Bk
TS17: midbrain Present 1Bk
TS17: telencephalon Present Regionally restricted 1Bk Expression is seen in the ventral telencephalon. In the dorsal telencephalon it is only seen in the most dorsomedial aspect.
Specimen 1Bn: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: telencephalon Present Regionally restricted 1Bn Expression is seen in the ventral telencephalon. In the dorsal telencephalon it is only seen in the most dorsomedial aspect.
Specimen 1Bo: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: telencephalon Present Regionally restricted 1Bo Expression is seen in the ventral telencephalon. In the dorsal telencephalon it is only seen in the most dorsomedial aspect.
Specimen 3Ca: embryonic day 10.5 (more )
Note: wild type
Structure Level Pattern Image Note
TS17: diencephalon Present 3Ca
TS17: midbrain Present 3Ca
Specimen 3Cb: embryonic day 10.5; Otx2tm2.1Imat/Otx2tm5Sia (more )
Structure Level Pattern Image Note
TS17: diencephalon Present 3Cb
TS17: midbrain Present 3Cb This region is nearly absent in this mutant.
Specimen not shown: embryonic day 9.5; Otx2tm6Sia/Otx2tm6Sia (more )
Structure Level Pattern Image Note
TS15: future brain Present Expression is diminished in this mutant.
Specimen 6Ca: embryonic day 10.5; Otx2tm2.1Imat/Otx2tm6Sia (more )
Structure Level Pattern Image Note
TS17: diencephalon Present 6Ca This region is only mildly reduced in this mutant.
TS17: midbrain Present 6Ca This region is only mildly reduced in this mutant.
Specimen 7Ba: embryonic day 10.5; Otx1tm1Sia/Otx1tm1Sia, Otx2tm5Sia/Otx2tm5Sia (more )
Structure Level Pattern Image Note
TS17: diencephalon Present 7Ba There is a residual domain of expression in this mutant.
TS17: midbrain Present 7Ba There is a residual domain of expression in this mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory