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Gene Expression Data
Assay Details
Assay
Reference: J:231660 Punzo D, et al., Age-Related Changes in d-Aspartate Oxidase Promoter Methylation Control Extracellular d-Aspartate Levels and Prevent Precocious Cell Death during Brain Aging. J Neurosci. 2016 Mar 9;36(10):3064-78
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6478319
Gene symbol: Th
Gene name: tyrosine hydroxylase
Antibody: anti-TH
Detection system: Secondary antibody coupled to Alexa Fluor 546
Results
Specimen 6a 3 months +/+: postnatal month 3 (more )
Note: Double labeled: red - Th; green - Casp3 (assay MGI:6478315).
Structure Level Pattern Image Note
TS28: substantia nigra Present 6a 3 months merge Ddo+/+
Specimen 6a 3 months -/-: postnatal month 3; Ddotm1Rdl/Ddotm1Rdl (more )
Note: Double labeled: red - Th; green - Casp3 (assay MGI:6478315).
Structure Level Pattern Image Note
TS28: substantia nigra Present 6a 3 months merge Ddo-/- The inset shows a significant reduction of immunodensity in a neuron.
Specimen 6a 6 months +/+: postnatal month 6 (more )
Note: Double labeled: red - Th; green - Casp3 (assay MGI:6478315).
Structure Level Pattern Image Note
TS28: substantia nigra Present 6a 6 months merge Ddo+/+
Specimen 6a 6 months -/-: postnatal month 6; Ddotm1Rdl/Ddotm1Rdl (more )
Note: Double labeled: red - Th; green - Casp3 (assay MGI:6478315).
Structure Level Pattern Image Note
TS28: substantia nigra Present 6a 6 months merge Ddo-/- The inset shows a significant reduction of immunodensity in a neuron.
Specimen 6a 13 months +/+: postnatal month 13 (more )
Note: Double labeled: red - Th; green - Casp3 (assay MGI:6478315).
Structure Level Pattern Image Note
TS28: substantia nigra Present 6a 13 months merge Ddo+/+
Specimen 6a 13 months -/-: postnatal month 13; Ddotm1Rdl/Ddotm1Rdl (more )
Note: Double labeled: red - Th; green - Casp3 (assay MGI:6478315).
Structure Level Pattern Image Note
TS28: substantia nigra Present 6a 13 months merge Ddo-/- The inset shows a significant reduction of immunodensity in a neuron.
Specimen 6c 3 months +/+: postnatal month 3 (more )
Note: Double labeled with Tunel (green).
Structure Level Pattern Image Note
TS28: substantia nigra Present 6c 3 months TH Ddo+/+
Specimen 6c 3 months -/-: postnatal month 3; Ddotm1Rdl/Ddotm1Rdl (more )
Note: Double labeled with Tunel (green).
Structure Level Pattern Image Note
TS28: substantia nigra Present 6c 3 months TH Ddo-/- The inset shows a significant reduction of immunodensity in a neuron.
Specimen 6c 6 months +/+: postnatal month 6 (more )
Note: Double labeled with Tunel (green).
Structure Level Pattern Image Note
TS28: substantia nigra Present 6c 6 monthsTH Ddo+/+
Specimen 6c 6 months -/-: postnatal month 6; Ddotm1Rdl/Ddotm1Rdl (more )
Note: Double labeled with Tunel (green).
Structure Level Pattern Image Note
TS28: substantia nigra Present 6c 6 monthsTH Ddo-/- The inset shows a significant reduction of immunodensity in a neuron.
Specimen 6c 13 months +/+: postnatal month 13 (more )
Note: Double labeled with Tunel (green).
Structure Level Pattern Image Note
TS28: substantia nigra Present 6c 13 months TH Ddo+/+
Specimen 6c 13 months -/-: postnatal month 13; Ddotm1Rdl/Ddotm1Rdl (more )
Note: Double labeled with Tunel (green).
Structure Level Pattern Image Note
TS28: substantia nigra Present 6c 13 months TH Ddo-/- The inset shows a significant reduction of immunodensity in a neuron.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory