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Gene Expression Data
Assay Details
Assay
Reference: J:296805 Chen S, et al., Runx2, osx, and dspp in tooth development. J Dent Res. 2009 Oct;88(10):904-9
Assay type: RNA in situ
MGI Accession ID: MGI:6473773
Gene symbol: Sp7
Gene name: Sp7 transcription factor 7
Probe: Osx probe6
Probe preparation: Antisense labelled with P32 RNA
Results
Specimen S1C: embryonic day 12.0 (more )
Structure Level Pattern Image Note
TS20: mandibular process mesenchyme Present Regionally restricted S1C Expression in mesenchymal condensates of forming bones and teeth in developing maxillary and mandibular arches. Overall expression levels lower than that of Runx2.
TS20: maxillary process mesenchyme Present Regionally restricted S1C Expression in mesenchymal condensates of forming bones and teeth in developing maxillary and mandibular arches. Overall expression levels lower than that of Runx2.

Specimen 1C: embryonic day 14.0 (more )
Structure Level Pattern Image Note
TS22: jaw mesenchyme Present Regionally restricted 1C Co-expression with Runx2 in mesenchymal cells in alveolar bone,
TS22: dental papilla Present Regionally restricted 1C Co-expression with Runx2 in dental papilla and dental follicle.
TS22: dental sac Present Regionally restricted 1C Co-expression with Runx2 in dental papilla and dental follicle.
TS22: tooth epithelium Trace 1C Expression barely seen in dental epithelium.

Specimen 1G: embryonic day 16.0 (more )
Structure Level Pattern Image Note
TS24: jaw mesenchyme Present Regionally restricted 1G Expression in differentiating osteogenic mesenchyme.
TS24: enamel epithelium Present Regionally restricted 1G Expression in ameloblasts.
TS24: tooth mesenchyme Present Regionally restricted 1G Expression in dental pulp cells.

Specimen 1K: embryonic day 18.0 (more )
Structure Level Pattern Image Note
TS26: jaw mesenchyme Present Regionally restricted 1K Expression in alveolar bone osteoblasts overlapped with Runx2 expression.
TS26: tooth mesenchyme Strong Regionally restricted 1K Intense expression in odontoblasts and dental pulp cells.

Specimen S1G: embryonic day 18.0 (more )
Structure Level Pattern Image Note
TS26: jaw mesenchyme Present Regionally restricted S1G Expression in alveolar bone osteoblasts overlapped with Runx2 expression.
TS26: tooth mesenchyme Strong Regionally restricted S1G Intense expression in odontoblasts and dental pulp cells.

Specimen S1K: embryonic day 18.0 (more )
Structure Level Pattern Image Note
TS26: jaw mesenchyme Present Regionally restricted S1K Expression in alveolar bone osteoblasts overlapped with Runx2 expression.
TS26: tooth mesenchyme Strong Regionally restricted S1K Intense expression in odontoblasts and dental pulp cells.

Specimen 2C: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: dental pulp Strong Regionally restricted 2C Intense expression in odontoblasts and dental pulp cells, in addition to osteoblasts.
TS27: jaw skeleton Strong Regionally restricted 2C Intense expression in odontoblasts and dental pulp cells, in addition to osteoblasts.

Specimen S2C: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: dental pulp Strong Regionally restricted S2C Intense expression in odontoblasts and dental pulp cells, in addition to osteoblasts.
TS27: jaw skeleton Strong Regionally restricted S2C Intense expression in odontoblasts and dental pulp cells, in addition to osteoblasts.

Specimen 2G: postnatal day 5 (more )
Structure Level Pattern Image Note
TS28: dental pulp Strong Regionally restricted 2G Similar expression patterns to those seen at PN1. Expression more intense in odontoblasts.

Specimen S2G: postnatal day 8 (more )
Structure Level Pattern Image Note
TS28: dental pulp Strong Regionally restricted S2G
TS28: tooth root Present S2G

Specimen 2K: postnatal day 10 (more )
Structure Level Pattern Image Note
TS28: dental pulp Strong Regionally restricted 2K High expression in odontoblasts and dental pulp cells.
TS28: alveolar process Present Regionally restricted 2K Expression also seen in bone
TS28: tooth substance Present Regionally restricted 2K Expression also seen in cemento-enamel junction.
TS28: tooth root Present 2K

Specimen S2K: postnatal day 10 (more )
Structure Level Pattern Image Note
TS28: dental pulp Strong Regionally restricted S2K High expression in odontoblasts and dental pulp cells.
TS28: alveolar process Present Regionally restricted S2K Expression also seen in bone
TS28: tooth substance Present Regionally restricted S2K Expression also seen in cemento-enamel junction.
TS28: tooth root Present S2K

Specimen S2O: postnatal day 14 (more )
Structure Level Pattern Image Note
TS28: dental pulp Strong Regionally restricted S2O High expression in odontoblasts and dental pulp cells.
TS28: alveolar process Present Regionally restricted S2O Expression also seen in bone
TS28: tooth substance Present Regionally restricted S2O Expression also seen in cemento-enamel junction.
TS28: tooth root Present S2O

Specimen S2S: postnatal day 14 (more )
Structure Level Pattern Image Note
TS28: dental pulp Strong Regionally restricted S2S High expression in odontoblasts and dental pulp cells.
TS28: alveolar process Present Regionally restricted S2S Expression also seen in bone
TS28: tooth substance Present Regionally restricted S2S Expression also seen in cemento-enamel junction.
TS28: tooth root Present S2S


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory