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Gene Expression Data
Assay Details
Assay
Reference: J:236232 Wang W, et al., Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate. PLoS Genet. 2016 Oct;12(10):e1006352
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6473201
Gene symbol: Ptch1
Gene name: patched 1
Antibody: Anti-Patched 1 (NB200-118)
Detection system: Secondary antibody coupled to Alexa Fluor 594
Results
Specimen 3D Smad2fx/fx: postnatal day 0; Smad2tm2Rob/Smad2tm2Rob (more )
Structure Level Pattern Image Note
TS27: tibia Present Regionally restricted 3D Smad2fx/fx Expression was detected in the growth plate.
Specimen 3D Smad2cko: postnatal day 0; Smad2tm2Rob/Smad2tm2Rob, Tg(Col2a1-cre)1Bhr/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: tibia Present Regionally restricted 3D Smad2cko Immunostaining demonstrated increased levels throughout the growth plates of the mutant compared with control. The increase was most evident in the resting zone.
Specimen 3D Smad3-/-: postnatal day 0; Smad3tm1Par/Smad3tm1Par (more )
Structure Level Pattern Image Note
TS27: tibia Present Regionally restricted 3D Smad3-/- Immunostaining demonstrated increased levels throughout the growth plates of the mutant compared with control.
Specimen 3D Smad2cko;Smad3-/-: postnatal day 0; Smad2tm2Rob/Smad2tm2Rob, Smad3tm1Par/Smad3tm1Par, Tg(Col2a1-cre)1Bhr/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: tibia Present Regionally restricted 3D Smad2cko;Smad3-/- Immunostaining demonstrated increased levels throughout the growth plates of the mutant compared with control. The increase was most evident in the resting zone.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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