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Gene Expression Data
Assay Details
Assay
Reference: J:236232 Wang W, et al., Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate. PLoS Genet. 2016 Oct;12(10):e1006352
Assay type: RNA in situ
MGI Accession ID: MGI:6473192
Gene symbol: Ihh
Gene name: Indian hedgehog
Probe: Ihh probe28
Probe preparation: Antisense labelled with S35 RNA
Results
Specimen 3A Smad2fx/fx: postnatal day 0; Smad2tm2Rob/Smad2tm2Rob (more )
Structure Level Pattern Image Note
TS27: tibia Present Regionally restricted 3A Smad2fx/fx Expression was detected in prehypertrophic chondrocytes.
Specimen 3A Smad2cko: postnatal day 0; Smad2tm2Rob/Smad2tm2Rob, Tg(Col2a1-cre)1Bhr/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: tibia Present Regionally restricted 3A Smad2cko The zone of Ihh expression was increased compared with control.
Specimen 3A Smad3-/-: postnatal day 0; Smad3tm1Par/Smad3tm1Par (more )
Structure Level Pattern Image Note
TS27: tibia Present Regionally restricted 3A Smad3-/- The zone of Ihh expression was increased compared with control.
Specimen 3A Smad2cko;Smad3-/-: postnatal day 0; Smad2tm2Rob/Smad2tm2Rob, Smad3tm1Par/Smad3tm1Par, Tg(Col2a1-cre)1Bhr/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: tibia Present Regionally restricted 3A Smad2cko;Smad3-/- The zone of Ihh expression was increased compared with control. The double mutant had elevated levels of Ihh compared to both single mutants.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory