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Gene Expression Data
Assay Details
Assay
Reference: J:173632 Hakanen J, et al., Netrin1 is required for neural and glial precursor migrations into the olfactory bulb. Dev Biol. 2011 Jul 1;355(1):101-14
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6472876
Gene symbol: Ntn1
Gene name: netrin 1
Reporter: lacZ
Direct Detection
Results
Specimen 1D: embryonic day 18.5; Ntn1Gt(IRESBetageo)1Pgr/Ntn1+ (more )
Structure Level Pattern Image Note
TS26: telencephalon ventricular layer Present Regionally restricted 1D Authors report that, in general, lacZ report expression co-localized with Ntn1 mRNA during development.
TS26: corpus striatum Present 1D
TS26: telencephalon septum Present 1D
TS26: rostral migratory stream Present 1D Expression in proximal migratory stream.

Specimen 1G: postnatal day 6; Ntn1Gt(IRESBetageo)1Pgr/Ntn1+ (more )
Structure Level Pattern Image Note
TS28: lateral ventricle Very strong Regionally restricted 1G Strongest expression in lateral walls of lateral ventricle and in ventral-most part of medial wall.
TS28: rostral migratory stream Strong Regionally restricted 1G Strong expression along whole horizontal rostral migratory stream.
TS28: main olfactory bulb granule cell layer Strong 1G

Specimen 1L: postnatal adult; Ntn1Gt(IRESBetageo)1Pgr/Ntn1+ (more )
Structure Level Pattern Image Note
TS28: spinal cord ependymal layer Present 1L

Specimen 1M: postnatal adult; Ntn1Gt(IRESBetageo)1Pgr/Ntn1+ (more )
Structure Level Pattern Image Note
TS28: lateral ventricle ependyma Strong Regionally restricted 1M Expression confined to one continuous later of cells next to ventricle lumen, corresponding to ependymal cells.
TS28: brain ependyma Present Regionally restricted 1M Expression in ependymal cells of more caudal brain regions.

Specimen 7A: embryonic day 18.5; Ntn1Gt(IRESBetageo)1Pgr/Ntn1+ (more )
Structure Level Pattern Image Note
TS26: rostral migratory stream Present Regionally restricted 7A Expressing cells entering proximal region of horizontal rostral migratory stream.
TS26: main olfactory bulb Absent 7A

Specimen 7B: embryonic day 18.5; Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr (more )
Structure Level Pattern Image Note
TS26: rostral migratory stream Present Regionally restricted 7B At all stages analyzed, expressing cells did not reach as far distally from ventricular zone as in controls.
TS26: main olfactory bulb Absent 7B

Specimen 7C: postnatal day 1; Ntn1Gt(IRESBetageo)1Pgr/Ntn1+ (more )
Structure Level Pattern Image Note
TS27: rostral migratory stream Present Regionally restricted 7C Region of expression extended more distally from ventricular zone in rostral migratory stream.
TS27: main olfactory bulb Absent 7C

Specimen 7D: postnatal day 1; Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr (more )
Structure Level Pattern Image Note
TS27: rostral migratory stream Present Regionally restricted 7D At all stages analyzed, expressing cells did not reach as far distally from ventricular zone as in controls. Expressing cells spread in a more broad area in proximal part of horizontal rostral migratory stream close to the ventricular zone.
TS27: main olfactory bulb Absent 7D

Specimen 7E: postnatal day 6; Ntn1Gt(IRESBetageo)1Pgr/Ntn1+ (more )
Structure Level Pattern Image Note
TS28: rostral migratory stream Present Widespread 7E Expression in cells along whole length of rostral migratory stream.
TS28: main olfactory bulb Present 7E Expressing cells reach the olfactory bulb.

Specimen 7F: postnatal day 6; Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr (more )
Structure Level Pattern Image Note
TS28: rostral migratory stream Present Regionally restricted 7F At all stages analyzed, expressing cells did not reach as far distally from ventricular zone as in controls.
TS28: main olfactory bulb Absent 7F Exprssing cells did not reach the olfactory bulb.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/21/2024
MGI 6.23
The Jackson Laboratory