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Gene Expression Data
Assay Details
Assay
Reference: J:237308 Biosse Duplan M, et al., Meckel's and condylar cartilages anomalies in achondroplasia result in defective development and growth of the mandible. Hum Mol Genet. 2016 Jul 15;25(14):2997-3010
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6468054
Gene symbol: Col10a1
Gene name: collagen, type X, alpha 1
Results
Specimen 2A WT: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: Meckel's cartilage Present Regionally restricted 2A WT ColX left , 2A WT ColX right Expression is in hypertrophic chondrocytes.
Specimen 2A Fgfr3Y367C/-: embryonic day 16.5; Fgfr3tm1Llm/Fgfr3+ (more )
Structure Level Pattern Image Note
TS24: Meckel's cartilage Present Regionally restricted 2A +/- ColX left , 2A +/- ColX right The size of the hypertrophic chondrocytes zone relative to the total size of the cartilage was reduced in this mutant compared to wild type as well the size of the individual cells.
Specimen 3E WT: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: mandible condylar process Present Regionally restricted 3E left bottom , 3E left top Expression is in the hypertrophic zone.
Specimen 3E Fgfr3Y367C/-: embryonic day 16.5; Fgfr3tm1Llm/Fgfr3+ (more )
Structure Level Pattern Image Note
TS24: mandible condylar process Present Regionally restricted 3E right top , 3E right bottom In this mutant the size of the hypertrophic zone in the cartilage was reduced compared to wild type as was the average size of individual cells.
Specimen 3F WT: postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: mandible condylar process Present Regionally restricted 3F left bottom , 3F left top Expression is in the hypertrophic zone.
Specimen 3F Fgfr3Y367C/-: postnatal day 21; Fgfr3tm1Llm/Fgfr3+ (more )
Structure Level Pattern Image Note
TS28: mandible condylar process Present Regionally restricted 3F right bottom , 3F right top In this mutant the size of the hypertrophic zone in the cartilage was reduced compared to wild type as was the average size of individual cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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