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Gene Expression Data
Assay Details
Assay
Reference: J:279114 Pandolfi EC, et al., Deletion of the Homeodomain Protein Six6 From GnRH Neurons Decreases GnRH Gene Expression, Resulting in Infertility. Endocrinology. 2019 Sep 1;160(9):2151-2164
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6452976
Gene symbol: Gnrh1
Gene name: gonadotropin releasing hormone 1
Results
Specimen 1a Cribriform Plate WT: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: head Present 1a WT
Specimen 1a Cribriform Plate KO: embryonic day 15.5; Six6tm1Rsd/Six6tm1Rsd (more )
Structure Level Pattern Image Note
TS23: head Trace 1a KO Drastic decreased in number of expressing neurons compared to E13.5.
Specimen 1c Nose WT: embryonic day 14.5 (more )
Note: Double labeled: green - Gnrh1; red - TUNEL.
Structure Level Pattern Image Note
TS22: nose Present 1c WT Merged , 1c WT GnRH
Specimen 1c Nose KO: embryonic day 14.5; Six6tm1Rsd/Six6tm1Rsd (more )
Note: Double labeled: green - Gnrh1; red - TUNEL.
Structure Level Pattern Image Note
TS22: nose Trace 1c KO GnRH , 1c KP Merged
Specimen 2c Cribriform Plate Cre -: embryonic day 13.5; Six6tm1.1Plm/Six6tm1.1Plm (more )
Structure Level Pattern Image Note
TS21: head Present 2c Cribriform Plate Cre -
Specimen 2c Cribriform Plate Cre +: embryonic day 13.5; Six6tm1.1Plm/Six6tm1.1Plm, Tg(Gnrh1-cre)1Dlc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: head Trace 2c Cribriform Plate Cre + Expression in significantly fewer neurons compared to control
Specimen 2c Nose Cre -: embryonic day 13.5; Six6tm1.1Plm/Six6tm1.1Plm (more )
Structure Level Pattern Image Note
TS21: nose Present 2c Nose Cre -
Specimen 2c Nose Cre +: embryonic day 13.5; Six6tm1.1Plm/Six6tm1.1Plm, Tg(Gnrh1-cre)1Dlc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: nose Trace 2c Nose Cre + Expression in significantly fewer neurons compared to control
Specimen 2d Cribriform Plate Cre -: embryonic day 17.5; Six6tm1.1Plm/Six6tm1.1Plm (more )
Structure Level Pattern Image Note
TS25: head Present 2d Cribriform Plate Cre -
Specimen 2d Cribriform Plate Cre +: embryonic day 17.5; Six6tm1.1Plm/Six6tm1.1Plm, Tg(Gnrh1-cre)1Dlc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS25: head Trace 2d Cribriform Plate Cre + Expression in significantly fewer neurons compared to control
Specimen 2d Nose Cre -: embryonic day 17.5; Six6tm1.1Plm/Six6tm1.1Plm (more )
Structure Level Pattern Image Note
TS25: nose Present 2d Nose Cre -
Specimen 2d Nose Cre +: embryonic day 17.5; Six6tm1.1Plm/Six6tm1.1Plm, Tg(Gnrh1-cre)1Dlc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS25: nose Trace 2d Nose Cre + Expression in significantly fewer neurons compared to control
Specimen 2d Hypothalamus Cre -: embryonic day 17.5; Six6tm1.1Plm/Six6tm1.1Plm (more )
Structure Level Pattern Image Note
TS25: hypothalamus Present 2d Hypothalamus Cre -
Specimen 2d Hypothalamus Cre +: embryonic day 17.5; Six6tm1.1Plm/Six6tm1.1Plm, Tg(Gnrh1-cre)1Dlc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS25: hypothalamus Trace 2d Hypothalamus Cre + Expression in significantly fewer neurons compared to control
Specimen 2e Hypothalamus Cre -: postnatal day 56; Six6tm1.1Plm/Six6tm1.1Plm (more )
Structure Level Pattern Image Note
TS28: hypothalamus Present 2e Hypothalamus Cre -
Specimen 2e Hypothalamus Cre +: postnatal day 56; Six6tm1.1Plm/Six6tm1.1Plm, Tg(Gnrh1-cre)1Dlc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: hypothalamus Trace 2e Hypothslamus Cre + Expression in significantly fewer neurons compared to control
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory