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Gene Expression Data
Assay Details
Assay
Reference: J:270210 Loo L, et al., Single-cell transcriptomic analysis of mouse neocortical development. Nat Commun. 2019 Jan 11;10(1):134
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6451471
Gene symbol: Dkk3
Gene name: dickkopf WNT signaling pathway inhibitor 3
Antibody: Anti-Dkk3 (ab2459)
Detection system: Secondary antibody coupled to Alexa Fluor 568
Results
Specimen 3c: embryonic day 14.5 (more )
Note: Triple labeled: green - Dkk3; blue - Sox2 (assay MGI:6451482); red - Reln (assay MGI:6451465).
Structure Level Pattern Image Note
TS22: cortical hem Present 3e , 3d , 3c
TS22: cerebral cortex Present Graded 3d , 3c , 3e Expression was detected in an intermediate population of cells between immature progenitors of the cortical hem and mature Cajal-Retzius cells. Many of these cells expressed Dkk3, Sox2, and Reln.
Specimen 3f: embryonic day 14.5 (more )
Note: Triple labeled: green - Dkk3; blue - Eomes (assay MGI:6451480); red - Reln (assay MGI:6451465).
Structure Level Pattern Image Note
TS22: cortical hem Present 3g , 3h , 3f
TS22: cerebral cortex Present Graded 3h , 3f , 3g Expression was detected in an intermediate population of cells between immature progenitors of the cortical hem and mature Cajal-Retzius cells. Many cells expressed a mixture of Dkk3, Eomes, and Reln.
Specimen S20a: embryonic day 14.5 (more )
Note: Triple labeled: green - Dkk3; blue - Eomes (assay MGI:6451480); red - Reln (assay MGI:6451465).
Structure Level Pattern Image Note
TS22: cerebral cortex Present Regionally restricted S20d , S20a , S20b Expression was detected in layer I. Cells were noted (arrow) that expressed both Dkk3 and Reln.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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