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Gene Expression Data
Assay Details
Assay
Reference: J:60591 Jablonka S, et al., Reduced survival motor neuron (Smn) gene dose in mice leads to motor neuron degeneration: an animal model for spinal muscular atrophy type III. Hum Mol Genet. 2000 Feb 12;9(3):341-6
Assay type: Western blot
MGI Accession ID: MGI:6451020
Gene symbol: Smn1
Gene name: survival motor neuron 1
Antibody: anti-Smn
Detection system: Secondary antibody coupled to horseradish peroxidase
Assay notes: Quantification is shown in figure 1c.
Results Image: 1b
 Sample Information Bands Other Sample Information
Lane AgeStructure 38 kDa Genetic BackgroundMutant Allele(s)Sex
E14 +/- E14.0 TS22: spinal cord Present involves: 129P2/OlaHsd Smn1tm1Msd/Smn1+Not Specified
E14 +/+ E14.0 TS22: spinal cord Present involves: 129P2/OlaHsd Not Specified
adult +/- P m 6 TS28: spinal cord Weak (a) involves: 129P2/OlaHsd Smn1tm1Msd/Smn1+Not Specified
adult +/+ P m 6 TS28: spinal cord Present involves: 129P2/OlaHsd Not Specified
Notes:
(a) There is an approximate 46% reduction in expression in the heterozygote.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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