Ndn Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:223046 Rieusset A, et al., Stochastic loss of silencing of the imprinted Ndn/NDN allele, in a mouse model and humans with prader-willi syndrome, has functional consequences. PLoS Genet. 2013;9(9):e1003752
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:6450170
Gene symbol:	Ndn
Gene name:	necdin, MAGE family member

Antibody:	anti-Necdin (07-565)
Detection system:	Secondary antibody coupled to Alexa Fluor 555

Results

2A WT IHC ©

Specimen 2A WT: embryonic day 12.5 (more

)

Structure	Level	Pattern	Image	Note
TS20: preoptic area	Present		2A WT IHC

2A Ndn IHC ©

Specimen 2A Ndn+m/-p: embryonic day 12.5; Ndn^tm1.1Mus/Ndn⁺ (more

)
Note: Maternally derived allele.

Structure	Level	Pattern	Image	Note
TS20: preoptic area	Weak	Regionally restricted	2A Ndn IHC

2B WT IHC ©

Specimen 2B WT: embryonic day 12.5 (more

)

Structure	Level	Pattern	Image	Note
TS20: hypothalamus	Present	Regionally restricted	2B WT IHC	Expression is in the supraoptic area.

2B Ndn IHC ©

Specimen 2B Ndn+m/-p: embryonic day 12.5; Ndn^tm1.1Mus/Ndn⁺ (more

)
Note: Maternally derived allele.

Structure	Level	Pattern	Image	Note
TS20: hypothalamus	Weak	Regionally restricted	2B Ndn IHC	Expression is in the supraoptic area.

2C WT IHC ©

Specimen 2C WT: embryonic day 12.5 (more

)

Structure	Level	Pattern	Image	Note
TS20: thalamus	Present		2C WT IHC

2C Ndn IHC ©

Specimen 2C Ndn+m/-p: embryonic day 12.5; Ndn^tm1.1Mus/Ndn⁺ (more

)
Note: Maternally derived allele.

Structure	Level	Pattern	Image	Note
TS20: thalamus	Weak	Regionally restricted	2C Ndn IHC

2D WT IHC ©

Specimen 2D WT: embryonic day 12.5 (more

)

Structure	Level	Pattern	Image	Note
TS20: pons	Present		2D WT IHC

2D Ndn IHC ©

Specimen 2D Ndn+m/-p: embryonic day 12.5; Ndn^tm1.1Mus/Ndn⁺ (more

)
Note: Maternally derived allele.

Structure	Level	Pattern	Image	Note
TS20: pons	Weak	Regionally restricted	2D Ndn IHC

2E WT IHC ©

Specimen 2E WT: embryonic day 12.5 (more

)

Structure	Level	Pattern	Image	Note
TS20: dorsal root ganglion	Present		2E WT IHC

2E Ndn IHC ©

Specimen 2E Ndn+m/-p: embryonic day 12.5; Ndn^tm1.1Mus/Ndn⁺ (more

)
Note: Maternally derived allele.

Structure	Level	Pattern	Image	Note
TS20: dorsal root ganglion	Weak	Regionally restricted	2E Ndn IHC

Specimen not shown E12.5: embryonic day 12.5; Ndn^tm1.1Mus/Ndn⁺ (more

)
Note: Maternally derived allele.

Structure	Level	Pattern	Note
TS20: spinal cord	Present
TS20: midbrain	Present	Regionally restricted	Expression is in the tegmentum.
TS20: prethalamus	Present	Regionally restricted	Expression is in the subthalamus.
TS20: cerebral cortex	Absent
TS20: myotome	Absent
TS20: tongue	Absent

3A WT ©

Specimen 3A WT: postnatal day 1 (more

)

Structure	Level	Pattern	Image	Note
TS27: brain	Present	Regionally restricted	3A WT	Expression is ventral.

3B WT ©

Specimen 3B WT: postnatal day 1 (more

)

Structure	Level	Pattern	Image	Note
TS27: dorsomedial hypothalamic nucleus	Present		3B WT

3B Ndn+m/-p ©

Specimen 3B Ndn+m/-p: postnatal day 1; Ndn^tm1.1Mus/Ndn⁺ (more

)
Note: Maternally derived allele.

Structure	Level	Pattern	Image	Note
TS27: dorsomedial hypothalamic nucleus	Present	Regionally restricted	3B Ndn+m/-p

3B Ndn-/- ©

Specimen 3B Ndn-/-: postnatal day 1; Ndn^tm1.1Mus/Ndn^tm1.1Mus (more

)

Structure	Level	Pattern	Image	Note
TS27: dorsomedial hypothalamic nucleus	Absent		3B Ndn-/-

3C WT ©

Specimen 3C WT: postnatal day 1 (more

)

Structure	Level	Pattern	Image	Note
TS27: dorsal raphe nucleus	Present		3C WT

3C Ndn+m/-p ©

Specimen 3C Ndn+m/-p: postnatal day 1; Ndn^tm1.1Mus/Ndn⁺ (more

)
Note: Maternally derived allele.

Structure	Level	Pattern	Image	Note
TS27: dorsal raphe nucleus	Present	Regionally restricted	3C Ndn+m/-p

3C Ndn-/- ©

Specimen 3C Ndn-/-: postnatal day 1; Ndn^tm1.1Mus/Ndn^tm1.1Mus (more

)

Structure	Level	Pattern	Image	Note
TS27: dorsal raphe nucleus	Absent		3C Ndn-/-

3D WT ©

Specimen 3D WT: postnatal day 1 (more

)

Structure	Level	Pattern	Image	Note
TS27: raphe magnus nucleus	Present		3D WT

3D Ndn+m/-p ©

Specimen 3D Ndn+m/-p: postnatal day 1; Ndn^tm1.1Mus/Ndn⁺ (more

)
Note: Maternally derived allele.

Structure	Level	Pattern	Image	Note
TS27: raphe magnus nucleus	Present	Regionally restricted	3D Ndn+m/-p

3D Ndn-/- ©

Specimen 3D Ndn-/-: postnatal day 1; Ndn^tm1.1Mus/Ndn^tm1.1Mus (more

)

Structure	Level	Pattern	Image	Note
TS27: raphe magnus nucleus	Absent		3D Ndn-/-

3E WT ©

Specimen 3E WT: postnatal day 1 (more

)

Structure	Level	Pattern	Image	Note
TS27: paraventricular thalamic nucleus	Present		3E WT

3E Ndn+m/-p ©

Specimen 3E Ndn+m/-p: postnatal day 1; Ndn^tm1.1Mus/Ndn⁺ (more

)
Note: Maternally derived allele.

Structure	Level	Pattern	Image	Note
TS27: paraventricular thalamic nucleus	Present	Regionally restricted	3E Ndn+m/-p

3E Ndn-/- ©

Specimen 3E Ndn-/-: postnatal day 1; Ndn^tm1.1Mus/Ndn^tm1.1Mus (more

)

Structure	Level	Pattern	Image	Note
TS27: paraventricular thalamic nucleus	Absent		3E Ndn-/-

S2A WT IHC ©

Specimen S2 A WT: embryonic day 12.5 (more

)

Structure	Level	Pattern	Image	Note
TS20: preoptic area	Present		S2A WT IHC

S2A Ndn-/- IHC ©

Specimen S2 A Ndn-/-: embryonic day 12.5; Ndn^tm1.1Mus/Ndn^tm1.1Mus (more

)
Note: Maternally derived allele.

Structure	Level	Pattern	Image	Note
TS20: preoptic area	Absent		S2A Ndn-/- IHC

S2B WT IHC ©

Specimen S2 B WT: embryonic day 12.5 (more

)

Structure	Level	Pattern	Image	Note
TS20: hypothalamus	Present	Regionally restricted	S2B WT IHC	Expression is in the supraoptic area.

S2B Ndn-/- IHC ©

Specimen S2 B Ndn-/-: embryonic day 12.5; Ndn^tm1.1Mus/Ndn^tm1.1Mus (more

)

Structure	Level	Pattern	Image	Note
TS20: hypothalamus	Absent		S2B Ndn-/- IHC

S2C WT IHC ©

Specimen S2 C WT: embryonic day 12.5 (more

)

Structure	Level	Pattern	Image	Note
TS20: thalamus	Present		S2C WT IHC

S2C Ndn-/- IHC ©

Specimen S2 C Ndn-/-: embryonic day 12.5; Ndn^tm1.1Mus/Ndn^tm1.1Mus (more

)

Structure	Level	Pattern	Image	Note
TS20: thalamus	Absent		S2C Ndn-/- IHC

S2D WT IHC ©

Specimen S2 D WT: embryonic day 12.5 (more

)

Structure	Level	Pattern	Image	Note
TS20: pons	Present		S2D WT IHC

S2D Ndn-/- IHC ©

Specimen S2 D Ndn-/-: embryonic day 12.5; Ndn^tm1.1Mus/Ndn^tm1.1Mus (more

)

Structure	Level	Pattern	Image	Note
TS20: pons	Absent		S2D Ndn-/- IHC

S2E WT IHC ©

Specimen S2 E WT: embryonic day 12.5 (more

)

Structure	Level	Pattern	Image	Note
TS20: dorsal root ganglion	Present		S2E WT IHC

S2E Ndn-/- IHC ©

Specimen S2 E Ndn-/-: embryonic day 12.5; Ndn^tm1.1Mus/Ndn^tm1.1Mus (more

)

Structure	Level	Pattern	Image	Note
TS20: dorsal root ganglion	Absent		S2E Ndn-/- IHC

S3A WT IHC ©

Specimen S3 A WT: embryonic day 10.5 (more

)

Structure	Level	Pattern	Image	Note
TS17: diencephalon	Present	Regionally restricted	S3A WT IHC	Expression is in the preoptic area.

S3A Ndn+m/-p IHC ©

Specimen S3 A Ndn+m/-p: embryonic day 10.5; Ndn^tm1.1Mus/Ndn⁺ (more

)
Note: Maternally derived allele.

Structure	Level	Pattern	Image	Note
TS17: diencephalon	Absent		S3A Ndn+m/-p IHC

S3B WT IHC ©

Specimen S3 B WT: embryonic day 10.5 (more

)

Structure	Level	Pattern	Image	Note
TS17: diencephalon	Present	Regionally restricted	S3B WT IHC	Expression is in the supraoptic area.

S3B Ndn+m/-p IHC ©

Specimen S3 B Ndn+m/-p: embryonic day 10.5; Ndn^tm1.1Mus/Ndn⁺ (more

)
Note: Maternally derived allele.

Structure	Level	Pattern	Image	Note
TS17: diencephalon	Absent		S3B Ndn+m/-p IHC

S3C WT IHC ©

Specimen S3 C WT: embryonic day 10.5 (more

)

Structure	Level	Pattern	Image	Note
TS17: diencephalon	Present	Regionally restricted	S3C WT IHC	Expression is in the thalamus.

S3C Ndn+m/-p IHC ©

Specimen S3 C Ndn+m/-p: embryonic day 10.5; Ndn^tm1.1Mus/Ndn⁺ (more

)
Note: Maternally derived allele.

Structure	Level	Pattern	Image	Note
TS17: diencephalon	Absent		S3C Ndn+m/-p IHC

S3D WT IHC ©

Specimen S3 D WT: embryonic day 10.5 (more

)

Structure	Level	Pattern	Image	Note
TS17: hindbrain	Present	Regionally restricted	S3D WT IHC	Expression is in the pons.

S3D Ndn+m/-p IHC ©

Specimen S3 D Ndn+m/-p: embryonic day 10.5; Ndn^tm1.1Mus/Ndn⁺ (more

)
Note: Maternally derived allele.

Structure	Level	Pattern	Image	Note
TS17: hindbrain	Absent		S3D Ndn+m/-p IHC

S3E WT IHC ©

Specimen S3 E WT: embryonic day 10.5 (more

)

Structure	Level	Pattern	Image	Note
TS17: dorsal root ganglion	Present		S3E WT IHC

S3E Ndn+m/-p IHC ©

Specimen S3 E Ndn+m/-p: embryonic day 10.5; Ndn^tm1.1Mus/Ndn⁺ (more

)
Note: Maternally derived allele.

Structure	Level	Pattern	Image	Note
TS17: dorsal root ganglion	Absent		S3E Ndn+m/-p IHC

S4A WT ©

Specimen S4 A WT: postnatal adult (more

)

Structure	Level	Pattern	Image	Note
TS28: telencephalon septum	Present		S4A WT

S4A Ndn+m/-p ©

Specimen S4 A Ndn+m/-p: postnatal adult; Ndn^tm1.1Mus/Ndn⁺ (more

)
Note: Maternally derived allele.

Structure	Level	Pattern	Image	Note
TS28: telencephalon septum	Present	Regionally restricted	S4A Ndn+m/-p

S4A Ndn-/- ©

Specimen S4 A Ndn-/-: postnatal adult; Ndn^tm1.1Mus/Ndn^tm1.1Mus (more

)

Structure	Level	Pattern	Image	Note
TS28: telencephalon septum	Absent		S4A Ndn-/-

S4B WT ©

Specimen S4 B WT: postnatal adult (more

)

Structure	Level	Pattern	Image	Note
TS28: thalamic nucleus	Present		S4B WT

S4B Ndn+m/-p ©

Specimen S4 B Ndn+m/-p: postnatal adult; Ndn^tm1.1Mus/Ndn⁺ (more

)
Note: Maternally derived allele.

Structure	Level	Pattern	Image	Note
TS28: thalamic nucleus	Present	Regionally restricted	S4B Ndn+m/-p

S4B Ndn-/- ©

Specimen S4 B Ndn-/-: postnatal adult; Ndn^tm1.1Mus/Ndn^tm1.1Mus (more

)

Structure	Level	Pattern	Image	Note
TS28: thalamic nucleus	Absent		S4B Ndn-/-

S4C WT ©

Specimen S4 C WT: postnatal adult (more

)

Structure	Level	Pattern	Image	Note
TS28: arcuate nucleus	Present		S4C WT

S4C Ndn+m/-p ©

Specimen S4 C Ndn+m/-p: postnatal adult; Ndn^tm1.1Mus/Ndn⁺ (more

)
Note: Maternally derived allele.

Structure	Level	Pattern	Image	Note
TS28: arcuate nucleus	Present	Regionally restricted	S4C Ndn+m/-p

S4C Ndn-/- ©

Specimen S4 C Ndn-/-: postnatal adult; Ndn^tm1.1Mus/Ndn^tm1.1Mus (more

)

Structure	Level	Pattern	Image	Note
TS28: arcuate nucleus	Absent		S4C Ndn-/-

S4D WT ©

Specimen S4 D WT: postnatal adult (more

)

Structure	Level	Pattern	Image	Note
TS28: paraventricular hypothalamic nucleus	Present		S4D WT
TS28: suprachiasmatic nucleus	Present		S4D WT

S4D Ndn+m/-p ©

Specimen S4 D Ndn+m/-p: postnatal adult; Ndn^tm1.1Mus/Ndn⁺ (more

)
Note: Maternally derived allele.

Structure	Level	Pattern	Image	Note
TS28: paraventricular hypothalamic nucleus	Present	Regionally restricted	S4D Ndn+m/-p
TS28: suprachiasmatic nucleus	Present	Regionally restricted	S4D Ndn+m/-p

S4D Ndn-/- ©

Specimen S4 D Ndn-/-: postnatal adult; Ndn^tm1.1Mus/Ndn^tm1.1Mus (more

)

Structure	Level	Pattern	Image	Note
TS28: paraventricular hypothalamic nucleus	Absent		S4D Ndn-/-
TS28: suprachiasmatic nucleus	Absent		S4D Ndn-/-

S6A WT IHC ©

Specimen S6 A WT: embryonic day 12.5 (more

)

Structure	Level	Pattern	Image	Note
TS20: telencephalon	Present	Regionally restricted	S6A WT IHC	Expression is in the septum.

Specimen S6 A Ndn+m/-p: embryonic day 12.5; Ndn^tm2Stw/Ndn⁺ (more

)
Note: Maternally derived allele.

Structure	Level	Pattern	Image	Note
TS20: telencephalon	Absent		S6A Ndn+m/-p IHC

S6B WT IHC ©

Specimen S6 B WT: embryonic day 12.5 (more

)

Structure	Level	Pattern	Image	Note
TS20: preoptic area	Present		S6B WT IHC

Specimen S6 B Ndn+m/-p: embryonic day 12.5; Ndn^tm2Stw/Ndn⁺ (more

)
Note: Maternally derived allele.

Structure	Level	Pattern	Image	Note
TS20: preoptic area	Absent		S6B Ndn+m/-p IHC

S6C WT IHC ©

Specimen S6 C WT: embryonic day 12.5 (more

)

Structure	Level	Pattern	Image	Note
TS20: thalamus	Present		S6C WT IHC

Specimen S6 C Ndn+m/-p: embryonic day 12.5; Ndn^tm2Stw/Ndn⁺ (more

)
Note: Maternally derived allele.

Structure	Level	Pattern	Image	Note
TS20: thalamus	Absent		S6C Ndn+m/-p IHC

S6D WT IHC ©

Specimen S6 D WT: embryonic day 12.5 (more

)

Structure	Level	Pattern	Image	Note
TS20: pons	Present		S6D WT IHC

Specimen S6 D Ndn+m/-p: embryonic day 12.5; Ndn^tm2Stw/Ndn⁺ (more

)
Note: Maternally derived allele.

Structure	Level	Pattern	Image	Note
TS20: pons	Absent		S6D Ndn+m/-p IHC

S6E WT IHC ©

Specimen S6 E WT: embryonic day 12.5 (more

)

Structure	Level	Pattern	Image	Note
TS20: dorsal root ganglion	Present		S6E WT IHC

Specimen S6 E Ndn+m/-p: embryonic day 12.5; Ndn^tm2Stw/Ndn⁺ (more

)
Note: Maternally derived allele.

Structure	Level	Pattern	Image	Note
TS20: dorsal root ganglion	Absent		S6E Ndn+m/-p IHC

Specimen not shown E14.5: embryonic day 14.5; Ndn^tm2Stw/Ndn⁺ (more

)
Note: Maternally derived allele.

Structure	Level	Pattern	Image	Note
TS22: dorsal root ganglion	Absent
TS22: pons	Absent
TS22: preoptic area	Absent
TS22: telencephalon septum	Absent
TS22: thalamus	Absent

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