Gene Expression Data
Assay Details
|
Assay
|
|
Reference:
|
J:198547
Neves G, et al., The LIM Homeodomain Protein Lhx6 Regulates Maturation of Interneurons and Network Excitability in the Mammalian Cortex. Cereb Cortex. 2013 Aug;23(8):1811-23
|
|
Assay type:
|
RNA in situ
|
|
MGI Accession ID:
|
MGI:6442587
|
|
Gene symbol:
|
Sst
|
|
Gene name:
|
somatostatin
|
|
Probe:
|
Sst cDNA3
|
|
Probe preparation:
|
Antisense RNA
|
|
|
Results
|
Specimen
4C:
postnatal day 30; Lhx6tm1Vpa/Lhx6 +
(more  )
Specimen
4C:
(close  )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Lhx6tm1Vpa/Lhx6+
|
|
Age:
|
postnatal day 30
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
Specimen
4D:
(close )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Lhx6tm1Vpa/Lhx6tm2Vpa
|
|
Age:
|
postnatal day 30
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS28: somatosensory cortex |
Present |
Regionally restricted |
4D
|
The number of positive interneurons was reduced in this mutant compared to controls (57%).
|
Specimen
8A:
embryonic day 13.5; Lhx6tm1Vpa/Lhx6 +
(more )
Specimen
8A:
(close )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Lhx6tm1Vpa/Lhx6+
|
|
Age:
|
embryonic day 13.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS21: cerebral cortex |
Present |
Regionally restricted |
8A
|
Expression is in interneurons.
|
Specimen
8B:
(close )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Lhx6tm1Vpa/Lhx6tm2Vpa
|
|
Age:
|
embryonic day 13.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS21: cerebral cortex |
Weak |
Regionally restricted |
8B
|
The density of positive cells is reduced in this mutant compared to controls.
|
Specimen
8C:
embryonic day 17.5; Lhx6tm1Vpa/Lhx6 +
(more )
Specimen
8C:
(close )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Lhx6tm1Vpa/Lhx6+
|
|
Age:
|
embryonic day 17.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS25: cerebral cortex |
Present |
Regionally restricted |
8C
|
Expression is in interneurons.
|
Specimen
8D:
(close )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Lhx6tm1Vpa/Lhx6tm2Vpa
|
|
Age:
|
embryonic day 17.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS25: cerebral cortex |
Weak |
Regionally restricted |
8D
|
The density of positive cells is reduced in this mutant compared to controls and to levels seen at E13.5.
|
Specimen
8E:
postnatal day 8; Lhx6tm1Vpa/Lhx6 +
(more )
Specimen
8E:
(close )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Lhx6tm1Vpa/Lhx6+
|
|
Age:
|
postnatal day 8
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS28: cerebral cortex |
Present |
Regionally restricted |
8E
|
Expression is in interneurons.
|
Specimen
8F:
(close )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Lhx6tm1Vpa/Lhx6tm2Vpa
|
|
Age:
|
postnatal day 8
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS28: cerebral cortex |
Weak |
|
8F
|
The amount of positive cells are about 50% of those seen in controls in interneurons deep in the cortex.
|
Specimen
not shown LacZ/-:
(close )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Lhx6tm1Vpa/Lhx6tm2Vpa
|
|
Age:
|
postnatal day 30
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS28: cerebral cortex |
Weak |
|
|
The amount of positive cells are about 50% of those seen in controls.
|
Specimen
not shown LacZ/+:
postnatal day 30; Lhx6tm1Vpa/Lhx6 +
(more )
Specimen
not shown LacZ/+:
(close )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Lhx6tm1Vpa/Lhx6+
|
|
Age:
|
postnatal day 30
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
|
Analysis Tools
