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Gene Expression Data
Assay Details
Assay
Reference: J:77320 Wilson ME, et al., Expression pattern of IAPP and prohormone convertase 1/3 reveals a distinctive set of endocrine cells in the embryonic pancreas. Mech Dev. 2002 Jul;115(1-2):171-6
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6441718
Gene symbol: Pcsk1
Gene name: proprotein convertase subtilisin/kexin type 1
Antibody: anti-PC1/3
Detection system: Secondary antibody coupled to fluorescein
Results
Specimen 1 e10.5 PC1/3: embryonic day 10.5 (more )
Note: Double labeled: green - Pcsk1; red - Gcg (assay MGI:6441719).
Structure Level Pattern Image Note
TS17: pancreas primordium Present Regionally restricted 1_e10.5 PC1/Glucagon , 1_e10.5 PC1/3 Expression predominantly in glucagon (Gcg)-expressing cells. At E10.5, expression in 90% of Gcg-expressing alpha cells.
Specimen 1 e14.5 PC1/3: embryonic day 14.5 (more )
Note: Double labeled: green - Pcsk1; red - Gcg (assay MGI:6441719).
Structure Level Pattern Image Note
TS22: pancreas Present Regionally restricted 1_e14.5 PC1/Glucagon , 1_e14.5 PC1/3 Expression in majority (69%) of Gcg-expressing cells.
Specimen 1 e15.5 PC1/3: embryonic day 15.5 (more )
Note: Double labeled: green - Pcsk1; red - Gcg (assay MGI:6441719).
Structure Level Pattern Image Note
TS23: pancreas Present Regionally restricted 1_e15.5 PC1/3 , 1_e15.5 PC1/Glucagon Expression in 30% of Gcg-expressing cells.
Specimen 1 e18.5 PC1/3: embryonic day 18.5 (more )
Note: Double labeled: green - Pcsk1; red - Gcg (assay MGI:6441719).
Structure Level Pattern Image Note
TS26: pancreas Present Regionally restricted 1_e18.5 PC1/Glucagon , 1_e18.5 PC1/3 Expression in less than a third of alpha cells.
Specimen 1 adult PC1/3: postnatal adult (more )
Note: Double labeled: green - Pcsk1; red - Gcg (assay MGI:6441719).
Structure Level Pattern Image Note
TS28: pancreas Present Regionally restricted 1_adult PC1/3 , 1_adult PC1/Glucagon No expression in alpha cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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