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Gene Expression Data
Assay Details
Assay
Reference: J:287264 Hael CE, et al., The transcriptional regulator PRDM12 is critical for Pomc expression in the mouse hypothalamus and controlling food intake, adiposity, and body weight. Mol Metab. 2020 Apr;34:43-53
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6436937
Gene symbol: Isl1
Gene name: ISL1 transcription factor, LIM/homeodomain
Antibody: clone 39.4D5
Detection system: Secondary antibody coupled to Alexa Fluor 647
Results
Specimen 3A +/+: embryonic day 12.5 (more )
Note: sagittal section
Structure Level Pattern Image Note
TS20: hypothalamus mantle layer Present 3A ISL1 +/+
Specimen 3A +/-: embryonic day 12.5; Prdm12tm2b(EUCOMM)Hmgu/Prdm12+ (more )
Note: sagittal section
Structure Level Pattern Image Note
TS20: hypothalamus mantle layer Present 3A ISL1 +/-
Specimen 3A -/-: embryonic day 12.5; Prdm12tm2b(EUCOMM)Hmgu/Prdm12tm2b(EUCOMM)Hmgu (more )
Note: sagittal section
Structure Level Pattern Image Note
TS20: hypothalamus mantle layer Present 3A ISL1 -/- Expression is unaffected in the mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory