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Gene Expression Data
Assay Details
Assay
Reference: J:272566 Yang R, et al., CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development. Development. 2019 Jan 25;146(2):dev169235
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6423301
Gene symbol: Pcna
Gene name: proliferating cell nuclear antigen
Antibody: PC10
Detection system: Secondary antibody coupled to horseradish peroxidase
Results
Specimen 3A: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: liver Present Regionally restricted 3A Expression was detected in proliferating hepatocytes.
Specimen 3A': embryonic day 16.5; Cdk5rap3tm1b(EUCOMM)Hmgu/Cdk5rap3tm1b(EUCOMM)Hmgu (more )
Structure Level Pattern Image Note
TS24: liver Present Regionally restricted 3A' The labeling was decreased in the knockout livers compared with control.
Specimen 5D: postnatal month 0.5 (more )
Note: The genetic background of the conditional control specimen was not specified.
Structure Level Pattern Image Note
TS28: liver Present Regionally restricted 5D Expression was detected in proliferating hepatocytes.
Specimen 5D': postnatal month 0.5; Cdk5rap3tm1c(EUCOMM)Hmgu/Cdk5rap3tm1c(EUCOMM)Hmgu, Tg(Foxa3-cre)1Khk/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: liver Present Regionally restricted 5D' The conditional knockout livers had a smaller number of PCNA-positive hepatocytes.
Specimen 5E: postnatal month 1 (more )
Note: The genetic background of the conditional control specimen was not specified.
Structure Level Pattern Image Note
TS28: liver Present Regionally restricted 5E Expression was detected in proliferating hepatocytes.
Specimen 5E': postnatal month 1; Cdk5rap3tm1c(EUCOMM)Hmgu/Cdk5rap3tm1c(EUCOMM)Hmgu, Tg(Foxa3-cre)1Khk/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: liver Present Regionally restricted 5E' The conditional knockout livers had a smaller number of PCNA-positive hepatocytes.
Specimen S3A: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: liver Present Regionally restricted S3A Expression was detected in proliferating hepatocytes.
Specimen S3A': embryonic day 14.5; Cdk5rap3tm1b(EUCOMM)Hmgu/Cdk5rap3tm1b(EUCOMM)Hmgu (more )
Structure Level Pattern Image Note
TS22: liver Present Regionally restricted S3A' The labeling was decreased in the knockout livers compared with control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory