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Gene Expression Data
Assay Details
Assay
Reference: J:199301 Lavado A, et al., Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators. Development. 2013 Aug;140(16):3323-34
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6416432
Gene symbol: Reln
Gene name: reelin
Results
Specimen 5E: embryonic day 14.5 (more )
Note: The genetic background of the conditional control specimen was not specified.
Structure Level Pattern Image Note
TS22: hippocampus Present Regionally restricted 5E Expression was detected in Cajal Retzius cells at the hippocampal subpial area.
Specimen 5F: embryonic day 14.5; Nf2tm2Gth/Nf2tm2Gth, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: hippocampus Present Regionally restricted 5F Significantly fewer immunolabeled Cajal Retzius cells were shown at the hippocampal subpial area in the mutant.
Specimen 5K: embryonic day 17.5 (more )
Note: The genetic background of the conditional control specimen was not specified. Double labeled: green - Reln; red - Prox1 (assay MGI:6416322).
Structure Level Pattern Image Note
TS25: hippocampus Present Regionally restricted 5K Expression was detected in the Cajal Retzius cells in the hippocampal fissure.
Specimen 5L: embryonic day 17.5; Nf2tm2Gth/Nf2tm2Gth, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: green - Reln; red - Prox1 (assay MGI:6416322).
Structure Level Pattern Image Note
TS25: hippocampus Present Regionally restricted 5L The hippocampal fissure with immunolabeled Cajal Retzius cells was much smaller in the mutant.
Specimen 5O: embryonic day 17.5 (more )
Note: The genetic background of the conditional control specimen was not specified. Double labeled: green - Reln; red - Gfap (assay MGI:6416434).
Structure Level Pattern Image Note
TS25: hippocampus Present Regionally restricted 5O Expression was detected in the Cajal Retzius cells in the hippocampal fissure.
Specimen 5P: embryonic day 17.5; Nf2tm2Gth/Nf2tm2Gth, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: green - Reln; red - Gfap (assay MGI:6416434).
Structure Level Pattern Image Note
TS25: hippocampus Present Regionally restricted 5P The hippocampal fissure with immunolabeled Cajal Retzius cells was much smaller in the mutant.
Specimen 8S: postnatal day 0; Nf2tm2Gth/Nf2+, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Control specimen. Double labeled: green - Reln; red - Gfap (assay MGI:6416434).
Structure Level Pattern Image Note
TS27: hippocampal fissure Present 8S
Specimen 8T: postnatal day 0; Nf2tm2Gth/Nf2tm2Gth, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: green - Reln; red - Gfap (assay MGI:6416434).
Structure Level Pattern Image Note
TS27: hippocampal fissure Present Regionally restricted 8T The hippocampal fissure with immunolabeled Cajal Retzius cells was much smaller in the mutant.
Specimen 8U: postnatal day 0; Nf2tm2Gth/Nf2+, Yap1tm1.1Eno/Yap1tm1.1Eno, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: green - Reln; red - Gfap (assay MGI:6416434).
Structure Level Pattern Image Note
TS27: hippocampal fissure Present 8U
Specimen 8V: postnatal day 0; Nf2tm2Gth/Nf2tm2Gth, Yap1tm1.1Eno/Yap1+, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: green - Reln; red - Gfap (assay MGI:6416434).
Structure Level Pattern Image Note
TS27: hippocampal fissure Present 8V
Specimen 8W: postnatal day 0; Nf2tm2Gth/Nf2tm2Gth, Yap1tm1.1Eno/Yap1tm1.1Eno, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: green - Reln; red - Gfap (assay MGI:6416434).
Structure Level Pattern Image Note
TS27: hippocampal fissure Present 8W In six out of ten Nf2<F/F>;Yap<F/F>;Emx1-Cre hippocampi, the hippocampal fissure appeared identical to those in control (8S) brains.
Specimen S9D: postnatal day 0; Nf2tm2Gth/Nf2tm2Gth, Yap1tm1.1Eno/Yap1tm1.1Eno, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: green - Reln; red - Gfap (assay MGI:6416434).
Structure Level Pattern Image Note
TS27: hippocampal fissure Present S9D In four out of ten Nf2<F/F>;Yap<F/F>;Emx1-Cre hippocampi, the hippocampal fissure showed partial rescue of the defects due to the Nf2 mutation.
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/14/2024
MGI 6.23 		The Jackson Laboratory