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Gene Expression Data
Assay Details
Assay
Reference: J:199301 Lavado A, et al., Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators. Development. 2013 Aug;140(16):3323-34
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6416426
Gene symbol: Trp73
Gene name: transformation related protein 73
Results
Specimen 5A: embryonic day 14.5 (more )
Note: The genetic background of the conditional control specimen was not specified. Double labeled: red - Trp73; green - Lmx1a (assay MGI:6416278).
Structure Level Pattern Image Note
TS22: hippocampus Present Regionally restricted 5A Expression was detected in Cajal Retzius cells at the hippocampal subpial area.
Specimen 5B: embryonic day 14.5; Nf2tm2Gth/Nf2tm2Gth, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: red - Trp73; green - Lmx1a (assay MGI:6416278).
Structure Level Pattern Image Note
TS22: hippocampus Present Regionally restricted 5B Significantly fewer immunolabeled Cajal Retzius cells were shown at the hippocampal subpial area in the mutant.
Specimen 5I: embryonic day 17.5 (more )
Note: The genetic background of the conditional control specimen was not specified. Double labeled: green - Trp73; red - Lmx1a (assay MGI:6416278).
Structure Level Pattern Image Note
TS25: hippocampus Present Regionally restricted 5I Expression was detected in the Cajal Retzius cells in the hippocampal fissure.
Specimen 5J: embryonic day 17.5; Nf2tm2Gth/Nf2tm2Gth, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: green - Trp73; red - Lmx1a (assay MGI:6416278).
Structure Level Pattern Image Note
TS25: hippocampus Present Regionally restricted 5J The hippocampal fissure with immunolabeled Cajal Retzius cells was much smaller in the mutant.
Specimen 8N: postnatal day 0; Nf2tm2Gth/Nf2+, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Control specimen.
Structure Level Pattern Image Note
TS27: hippocampal fissure Present 8N
Specimen 8O: postnatal day 0; Nf2tm2Gth/Nf2tm2Gth, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: hippocampal fissure Present 8O The hippocampal fissure was much smaller in the mutant.
Specimen 8P: postnatal day 0; Nf2tm2Gth/Nf2+, Yap1tm1.1Eno/Yap1tm1.1Eno, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: hippocampal fissure Present 8P
Specimen 8Q: postnatal day 0; Nf2tm2Gth/Nf2tm2Gth, Yap1tm1.1Eno/Yap1+, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: hippocampal fissure Present 8Q
Specimen 8R: postnatal day 0; Nf2tm2Gth/Nf2tm2Gth, Yap1tm1.1Eno/Yap1tm1.1Eno, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: hippocampal fissure Present 8R In six out of ten Nf2<F/F>;Yap<F/F>;Emx1-Cre hippocampi, the hippocampal fissure appeared identical to those in control (8N) brains.
Specimen S9C: postnatal day 0; Nf2tm2Gth/Nf2tm2Gth, Yap1tm1.1Eno/Yap1tm1.1Eno, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: hippocampal fissure Present S9C In four out of ten Nf2<F/F>;Yap<F/F>;Emx1-Cre hippocampi, the hippocampal fissure showed partial rescue of the defects due to the Nf2 mutation.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory