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Gene Expression Data
Assay Details
Assay
Reference: J:199301 Lavado A, et al., Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators. Development. 2013 Aug;140(16):3323-34
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6416328
Gene symbol: Sox2
Gene name: SRY (sex determining region Y)-box 2
Antibody: Anti-Sox2 (Y-17; sc-17320)
Assay notes: Two antibodies were described MGI:5430034 and MGI:5822879, but the one used in this assay was not specified. Either antibody could have been used.
Results
Specimen 4K: embryonic day 15.5 (more )
Note: The genetic background of the conditional control specimen was not specified. Triple labeled: red - Sox2; green - Eomes (assay MGI:6416157); blue - Bcl11b (assay MGI:6416329).
Structure Level Pattern Image Note
TS23: hippocampus Present Regionally restricted 4K Expression was detected in the hippocampal progenitor zone.
Specimen 4L: embryonic day 15.5; Nf2tm2Gth/Nf2tm2Gth, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Triple labeled: red - Sox2; green - Eomes (assay MGI:6416157); blue - Bcl11b (assay MGI:6416329).
Structure Level Pattern Image Note
TS23: hippocampus Present 4L The Sox2+ hippocampal progenitor zone was notably wider in the conditional mutant.
Specimen S6A: embryonic day 15.5 (more )
Note: The genetic background of the conditional control specimen was not specified. Triple labeled: red - Sox2; green - Eomes (assay MGI:6416157); blue - Bcl11b (assay MGI:6416329).
Structure Level Pattern Image Note
TS23: cerebral cortex ventricular layer Present Regionally restricted S6A Expression was detected in the neuroprogenitor cells in the neocortex.
Specimen S6B: embryonic day 15.5; Nf2tm2Gth/Nf2tm2Gth, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Triple labeled: red - Sox2; green - Eomes (assay MGI:6416157); blue - Bcl11b (assay MGI:6416329).
Structure Level Pattern Image Note
TS23: cerebral cortex ventricular layer Present Regionally restricted S6B The conditional mutant Sox2+ neuroprogenitor cell population was expanded approximately 50% compared to control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory