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Gene Expression Data
Assay Details
Assay
Reference: J:174609 Ahrens MJ, et al., A re-evaluation of two key reagents for in vivo studies of Wnt signaling. Dev Dyn. 2011 Sep;240(9):2060-8
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6403223
Gene symbol: Casp3
Gene name: caspase 3
Antibody: anti-cleaved Caspase3
Detection system: Secondary antibody coupled to Alexa Fluor 488
Assay notes: The antibody used recognizes the cleaved form of the protein.
Results
Specimen 4B Wt: embryonic day 18.5; Ctnnb1tm2Kem/Ctnnb1+, Tg(Col2a1-cre)1Bhr/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: femur Present Regionally restricted 4B Caspase3 Wt Expression is in apoptotic cells in hypertrophic chondrocytes.
Specimen 4B Mut: embryonic day 18.5; Ctnnb1tm2Kem/Ctnnb1tm2Kem, Tg(Col2a1-cre)1Bhr/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: femur Strong Regionally restricted 4B Caspase3 Mut There is an increase in apoptotic cells in hypertrophic chondrocytes of the mutant growth plates.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory