About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:266583 Baumgartner M, et al., Minor spliceosome inactivation causes microcephaly, owing to cell cycle defects and death of self-amplifying radial glial cells. Development. 2018 Aug 28;145(17):dev166322
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6400919
Gene symbol: Pax6
Gene name: paired box 6
Results
Specimen 4F left: embryonic day 12.5; Rnu11tm1.1Rank/Rnu11tm1.1Rank, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: green - Pax6; magenta - H2ax (assay MGI:6400789).
Structure Level Pattern Image Note
TS20: neocortex Present Regionally restricted 4F Pax6 46.3% of H2ax-immunopositive cells in the mutant pallium were also Pax6-immunopositive radial glial cells.
Specimen 5D control: embryonic day 12.5; Rnu11tm1.1Rank/Rnu11+, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: magenta - Pax6; green - Aurkb (assay MGI:6400916).
Structure Level Pattern Image Note
TS20: neocortex Present Regionally restricted 5D E12 ctrl Expression was detected in radial glial cells.
Specimen 5D mutant: embryonic day 12.5; Rnu11tm1.1Rank/Rnu11tm1.1Rank, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: magenta - Pax6; green - Aurkb (assay MGI:6400916).
Structure Level Pattern Image Note
TS20: neocortex Present Regionally restricted 5D E12 mut A significantly higher percentage of mitotic Aurkb+/Pax6+ radial glial cells were in prometaphase+metaphase in the E12 mutant pallium than in the control. Prophase, anaphase, and telophase cells were not significantly different compared to control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory