Gene Expression Data
Assay Details
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Assay
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Reference:
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J:139570
Capellini TD, et al., Pbx1/Pbx2 govern axial skeletal development by controlling Polycomb and Hox in mesoderm and Pax1/Pax9 in sclerotome. Dev Biol. 2008 Sep 15;321(2):500-14
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Assay type:
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Immunohistochemistry
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MGI Accession ID:
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MGI:6391105
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Gene symbol:
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Nefm
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Gene name:
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neurofilament, medium polypeptide
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Results
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Specimen
E11.5 WT not shown:
embryonic day 11.5
(more  )
Specimen
E11.5 WT not shown:
(close  )
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Genetic Background:
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involves: Black Swiss * C57BL/6
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Age:
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embryonic day 11.5
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Sex:
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Not Specified
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Type:
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whole mount
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Fixation:
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4% Paraformaldehyde
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| Structure |
Level |
Pattern |
Image |
Note |
| TS19: peripheral nerve |
Present |
Regionally restricted |
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Expression in peripheral nerves.
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Specimen
5B WT:
embryonic day 12.25
(more )
Specimen
5B WT:
(close )
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Genetic Background:
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involves: Black Swiss * C57BL/6
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Age:
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embryonic day 12.25
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Sex:
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Not Specified
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Type:
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whole mount
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Fixation:
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4% Paraformaldehyde
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| Structure |
Level |
Pattern |
Image |
Note |
| TS20: peripheral nerve |
Present |
Regionally restricted |
5B WT
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Expression in developing peripheral nerves enterming the hindlimb.
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Specimen
5B Pbx1-/-;Pbx2+/-:
(close )
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Genetic Background:
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involves: 129S/Sv * Black Swiss * C57BL/6
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Mutant Allele(s):
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Pbx1tm1Mlc/Pbx1tm1Mlc
Pbx2tm1Mlc/Pbx2+
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Age:
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embryonic day 12.25
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Sex:
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Not Specified
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Type:
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whole mount
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Fixation:
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4% Paraformaldehyde
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| Structure |
Level |
Pattern |
Image |
Note |
| TS20: peripheral nerve |
Present |
Regionally restricted |
5B Pbx1-/-;Pbx2+/-
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Severely compromised neurogenesis more caudally along embryo, specifically in lateral and ventral extent of projecting neural fibers, compared to wild type. No expresssion in peripheral nerves entering the hindlimb.
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Analysis Tools
