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Gene Expression Data
Assay Details
Assay
Reference: J:135657 Hayashi T, et al., Hesr1 and Hesr2 may act as early effectors of Notch signaling in the developing cochlea. Dev Biol. 2008 Apr 1;316(1):87-99
Assay type: RNA in situ
MGI Accession ID: MGI:6385192
Gene symbol: Hey2
Gene name: hairy/enhancer-of-split related with YRPW motif 2
Probe: Hesr2 probe1
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 1B: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: cochlear duct Present Regionally restricted 1B Narrow band of expression, nested in Hesr1 expression region on ventral side of cochlear duct.
Specimen 1E: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: cochlear duct Present Regionally restricted 1E Narrow band of expression, nested in Hesr1 expression region on ventral side of cochlear duct.
Specimen 1G: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: cochlear duct Strong Regionally restricted 1G Expression more intense at all turns of cochlea, overlapping almost entirely with Hesr1 expression domain.
Specimen 1I: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: cochlear duct Weak Regionally restricted 1I Expression downregulated but continues in apex. No expression in basal turns (1 and 2).
Specimen 1K: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: cochlear duct Weak Regionally restricted 1K Expression dowregulated but continues at apex. No expression in turns 1,2 and 3.
Specimen P0 ont shown: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: cochlea Absent
Specimen S1B: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: inner ear vestibular component Absent S1B No expression in vestibular system at any age examined.
Specimen S1E: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: posterior semicircular canal epithelium Absent S1E No expression in vestibular system at any age examined.
Specimen S1I: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: saccule Absent S1I No expression in vestibular system at any age examined.
Specimen 3A: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: cochlear duct Present Regionally restricted 3A Expression throughout cochlea (turns 1 to 4).
Specimen 4E: embryonic day 13.5 (more )
Note: Double labeled: purple - Hesr2 (Hey2); red - p27kip1 (Cdkn1b assay MGI:6385184).
Structure Level Pattern Image Note
TS21: cochlear duct Present Regionally restricted 4E Expression in middle part of cochlear duct. Expression domain included p27kip1 (Cdkn1b) domain but extends more mdeially.
Specimen 4F: embryonic day 15.5 (more )
Note: Double labeled: purple - Hesr2 (Hey2); red - p27kip1 (Cdkn1b assay MGI:6385184).
Structure Level Pattern Image Note
TS23: cochlear duct Present Regionally restricted 4F Expression in basal turn (turn 1). Expression more restricted than that of Hesr1 and is completely contained withn p27kip1 (Cdkn1b) domain.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory