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Gene Expression Data
Assay Details
Assay
Reference: J:126341 Nam JS, et al., Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimb. Dev Biol. 2007 Nov 1;311(1):124-35
Assay type: RNA in situ
MGI Accession ID: MGI:6377609
Gene symbol: Fgf8
Gene name: fibroblast growth factor 8
Probe: Fgf8 probe96
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen E9.5 +/+ not shown: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: forelimb bud ectoderm Present
Specimen E9.5 +/- not shown: embryonic day 9.5; Rspo2tm1Nuv/Rspo2+ (more )
Structure Level Pattern Image Note
TS15: forelimb bud ectoderm Present
Specimen E9.5 -/- not shown: embryonic day 9.5; Rspo2tm1Nuv/Rspo2tm1Nuv (more )
Structure Level Pattern Image Note
TS15: forelimb bud ectoderm Present Expression levels comparable to +/+ and +/- embryos.
Specimen 3A: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: forelimb bud apical ectodermal ridge Present 3A
Specimen 3B: embryonic day 10.5; Rspo2tm1Nuv/Rspo2+ (more )
Structure Level Pattern Image Note
TS17: forelimb bud apical ectodermal ridge Present 3B
Specimen 3C: embryonic day 10.5; Rspo2tm1Nuv/Rspo2tm1Nuv (more )
Structure Level Pattern Image Note
TS17: forelimb bud apical ectodermal ridge Present 3C Expression levels comparable to +/+ and +/- embryos.
Specimen 3D: embryonic day 10.25 (more )
Structure Level Pattern Image Note
TS16: hindlimb bud ectoderm Present 3D
Specimen 3E: embryonic day 10.25; Rspo2tm1Nuv/Rspo2+ (more )
Structure Level Pattern Image Note
TS16: hindlimb bud ectoderm Present 3E
Specimen 3F: embryonic day 10.25; Rspo2tm1Nuv/Rspo2tm1Nuv (more )
Structure Level Pattern Image Note
TS16: hindlimb bud ectoderm Present 3F Expression normal or slightly reduced compared to +/+ and +/- embryos.
Specimen 3G: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: hindlimb bud apical ectodermal ridge Present 3G
Specimen 3H: embryonic day 10.5; Rspo2tm1Nuv/Rspo2+ (more )
Structure Level Pattern Image Note
TS17: hindlimb bud apical ectodermal ridge Present 3H
Specimen 3I: embryonic day 10.5; Rspo2tm1Nuv/Rspo2tm1Nuv (more )
Structure Level Pattern Image Note
TS17: hindlimb bud apical ectodermal ridge Weak Regionally restricted 3I Expression domain and level reduced compared to +/+ and +/- embryos, more prominent in left than in right hindlimb.
Specimen 3J: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: hindlimb bud apical ectodermal ridge Present 3J
Specimen 3K: embryonic day 10.5; Rspo2tm1Nuv/Rspo2+ (more )
Structure Level Pattern Image Note
TS17: hindlimb bud apical ectodermal ridge Present 3K
Specimen 3L: embryonic day 10.5; Rspo2tm1Nuv/Rspo2tm1Nuv (more )
Structure Level Pattern Image Note
TS17: hindlimb bud apical ectodermal ridge Weak Regionally restricted 3L Expression domain and level reduced compared to +/+ and +/- embryos, more prominent in left than in right hindlimb.
Specimen 3M: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: footplate apical ectodermal ridge Present 3M
Specimen 3N: embryonic day 11.5; Rspo2tm1Nuv/Rspo2+ (more )
Structure Level Pattern Image Note
TS19: footplate apical ectodermal ridge Present 3N
Specimen 3O: embryonic day 11.5; Rspo2tm1Nuv/Rspo2tm1Nuv (more )
Structure Level Pattern Image Note
TS19: footplate apical ectodermal ridge Trace 3O Expression severely reduced compared to +/+ and +/- embryos.
Specimen 3P: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: footplate apical ectodermal ridge Present 3P
Specimen 3Q: embryonic day 11.5; Rspo2tm1Nuv/Rspo2+ (more )
Structure Level Pattern Image Note
TS19: footplate apical ectodermal ridge Present 3Q
Specimen 3R: embryonic day 11.5; Rspo2tm1Nuv/Rspo2tm1Nuv (more )
Structure Level Pattern Image Note
TS19: footplate apical ectodermal ridge Weak Regionally restricted 3R Expression domain and level reduced compared to +/+ and +/- embryos, more prominent in left than in right hindlimb.
Specimen 3S: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: footplate apical ectodermal ridge Present 3S
Specimen 3T: embryonic day 11.5; Rspo2tm1Nuv/Rspo2+ (more )
Structure Level Pattern Image Note
TS19: footplate apical ectodermal ridge Present 3T
Specimen 3U: embryonic day 11.5; Rspo2tm1Nuv/Rspo2tm1Nuv (more )
Structure Level Pattern Image Note
TS19: footplate apical ectodermal ridge Trace 3U Expression severely reduced compared to +/+ and +/- embryos.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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01/28/2026
MGI 6.24 		The Jackson Laboratory