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Gene Expression Data
Assay Details
Assay
Reference: J:119274 Georgia S, et al., p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors. Dev Biol. 2006 Oct 1;298(1):22-31
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6364171
Gene symbol: Cdkn1c
Gene name: cyclin dependent kinase inhibitor 1C
Antibody: p57kip2 antibody (M-20; sc-1039)
Detection system: Secondary antibody coupled to Cy3
Results
Specimen 1B: embryonic day 10.5 (more )
Note: Double labeled: red - p57 (Cdkn1c); green - Pdx1 (assay MGI:6364172).
Structure Level Pattern Image Note
TS17: pancreas primordium Present Regionally restricted 1B Expression restricted to a subset of progenitor cells within epithelial bud.
Specimen 1C: embryonic day 11.5 (more )
Note: Double labeled: red - p57 (Cdkn1c); green - Pdx1 (assay MGI:6364172).
Structure Level Pattern Image Note
TS19: pancreas primordium epithelium Present Regionally restricted 1C Expression in a subset of epithelial progenitor cells.
TS19: pancreas primordium mesenchyme Strong Regionally restricted 1C Strong expression in mesenchyme cells surrounding the epithelial bud.
Specimen E11.5 not shown: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: pancreas primordium ventral bud Present
Specimen 1D: embryonic day 12.5 (more )
Note: Double labeled: red - p57 (Cdkn1c); green - Pdx1 (assay MGI:6364172).
Structure Level Pattern Image Note
TS20: pancreas epithelium Weak 1D Expression in very few epithelial progenitor cells.
TS20: pancreas mesenchyme Strong 1D
Specimen 1E: embryonic day 11.5 (more )
Note: Triple labeled: red - p57 (Cdkn1c); green - BrdU; blue - Gcg (assay MGI:6364173).
Structure Level Pattern Image Note
TS19: pancreas primordium Present Regionally restricted 1E No expression in cells that have incorporated BrdU or expressing Glucagon (Gcg)
Specimen 1F: embryonic day 11.5 (more )
Note: Triple labeled: red - p57 (Cdkn1c); green - Ngn3 (Neurog3 assay MGI:6364175).
Structure Level Pattern Image Note
TS19: pancreas primordium Present Regionally restricted 1F
Specimen 1G: embryonic day 11.5 (more )
Note: Double labeled: red - p57 (Cdkn1c); green - Isl1 (assay MGI:6364176).
Structure Level Pattern Image Note
TS19: pancreas primordium Present Regionally restricted 1G No co-expression with Isl1.
Specimen 4B/C: embryonic day 9.5 (more )
Note: Double labeled: red - p57 (Cdkn1c); green - Pdx1 (assay MGI:6364172).
Structure Level Pattern Image Note
TS15: pancreas primordium Trace Regionally restricted 4B , 4C Expression in very few epithelial cells within the pancreatic bud.
Specimen E10.5 not shown: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: pancreas primordium Ambiguous Authors report expressing-cells were depleted by E10.5
Specimen 4E/F: embryonic day 10.5; Hes1tm1Fgu/Hes1tm1Fgu (more )
Note: Double labeled: red - p57 (Cdkn1c); green - Pdx1 (assay MGI:6364172).
Structure Level Pattern Image Note
TS17: pancreas primordium dorsal bud Strong Widespread 4F , 4E Expression dramatically upregulated. Expression in almost all epithelial cells within dorsal pancreatic bud.
Specimen ventral bud not shown: embryonic day 10.5; Hes1tm1Fgu/Hes1tm1Fgu (more )
Structure Level Pattern Image Note
TS17: pancreas primordium ventral bud Present Expression in progenitor cells of ventral bud.
Specimen 4H/J: embryonic day 10.5 (more )
Note: Double labeled: red - p57 (Cdkn1c); green - Hes1 (assay MGI:6364181).
Structure Level Pattern Image Note
TS17: pancreas primordium Present Regionally restricted 4H , 4J No co-expression with Hes1.
Specimen neural tube not shown: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: neural tube Present Regionally restricted No co-expression with Hes1.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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