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Gene Expression Data
Assay Details
Assay
Reference: J:118802 Blak AA, et al., Fgfr2 and Fgfr3 are not required for patterning and maintenance of the midbrain and anterior hindbrain. Dev Biol. 2007 Mar 1;303(1):231-43
Assay type: RNA in situ
MGI Accession ID: MGI:6363697
Gene symbol: Th
Gene name: tyrosine hydroxylase
Probe: Th probe12
Probe preparation: Antisense RNA
Visualized with: Autoradiography
Results
Specimen 2Ba: embryonic day 12.5; Fgfr2tm1Wrst/Fgfr2tm1Wrst (more )
Structure Level Pattern Image Note
TS20: midbrain floor plate Present Regionally restricted 2Ba Expression in floor plate and basal plate of ventral midbrain, marking future dopaminergic neurons of midbrain.

Specimen 2Ba': embryonic day 12.5; En1tm2(cre)Wrst/En1+, Fgfr2tm1Wrst/Fgfr2tm1Wrst (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: midbrain floor plate Present Regionally restricted 2Ba' Expression unchanged compared to control.

Specimen 3Aa: embryonic day 12.5; Fgfr2tm1Wrst/Fgfr2tm1Wrst (more )
Structure Level Pattern Image Note
TS20: midbrain Present Regionally restricted 3Aa Expression in ventral midbrain, marking presumptive dopaminiergic neurons of midbrain.

Specimen 3Aa': embryonic day 12.5; En1tm2(cre)Wrst/En1+, Fgfr2tm1Wrst/Fgfr2tm1Wrst (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: midbrain Present Regionally restricted 3Aa' Expression unchanged compared to control.

Specimen 3Ab: embryonic day 12.5; Fgfr2tm1Wrst/Fgfr2tm1Wrst (more )
Structure Level Pattern Image Note
TS20: hindbrain Present Regionally restricted 3Ab Expression in presumptive locus coeruleus (ventral rhombomere 1).

Specimen 3Ab': embryonic day 12.5; En1tm2(cre)Wrst/En1+, Fgfr2tm1Wrst/Fgfr2tm1Wrst (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: hindbrain Present Regionally restricted 3Ab' Expression unchanged compared to control.

Specimen 3Ba: postnatal adult; Fgfr2tm1Wrst/Fgfr2tm1Wrst (more )
Structure Level Pattern Image Note
TS28: substantia nigra Present Regionally restricted 3Ba Expression in dopaminergic neurons of substantia nigra and ventral tegmental area.
TS28: ventral tegmental area Present Regionally restricted 3Ba Expression in dopaminergic neurons of substantia nigra and ventral tegmental area.

Specimen 3Ba': postnatal adult; En1tm2(cre)Wrst/En1+, Fgfr2tm1Wrst/Fgfr2tm1Wrst (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: substantia nigra Present Regionally restricted 3Ba' Expression unchanged compared to control.
TS28: ventral tegmental area Present Regionally restricted 3Ba' Expression unchanged compared to control.

Specimen 3Bb: postnatal adult; Fgfr2tm1Wrst/Fgfr2tm1Wrst (more )
Structure Level Pattern Image Note
TS28: locus coeruleus Present Regionally restricted 3Bb Expression in noradrenergic neuros of the locus coeruleus.

Specimen 3Bb': postnatal adult; En1tm2(cre)Wrst/En1+, Fgfr2tm1Wrst/Fgfr2tm1Wrst (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: locus coeruleus Present Regionally restricted 3Bb' Expression unchanged compared to control.

Specimen 4Ba: postnatal adult (more )
Structure Level Pattern Image Note
TS28: substantia nigra Present Regionally restricted 4Ba Expression in dopaminergic neurons of substantia nigra and ventral tegmental area.
TS28: ventral tegmental area Present Regionally restricted 4Ba Expression in dopaminergic neurons of substantia nigra and ventral tegmental area.

Specimen 4Ba': postnatal adult; Fgfr3tm1Dor/Fgfr3tm1Dor (more )
Structure Level Pattern Image Note
TS28: substantia nigra Present Regionally restricted 4Ba' Expression unchanged compared to control.
TS28: ventral tegmental area Present Regionally restricted 4Ba' Expression unchanged compared to control.


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory