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Gene Expression Data
Assay Details
Assay
Reference: J:108723 Andersson O, et al., Synergistic interaction between Gdf1 and Nodal during anterior axis development. Dev Biol. 2006 May 15;293(2):370-81
Assay type: RNA in situ
MGI Accession ID: MGI:6363326
Gene symbol: Foxa2
Gene name: forkhead box A2
Probe: Foxa2 probe21
Probe preparation: labelled with digoxigenin
Results
Specimen 2A WT: embryonic day 7.0 (more )
Note: Mid-streak
Structure Level Pattern Image Note
TS10: primitive streak Present Regionally restricted 2A WT Expression in anterior primitive streak.
Specimen 2A G-/-: embryonic day 7.0; Gdf1tm1Sjl/Gdf1tm1Sjl (more )
Note: Mid-streak
Structure Level Pattern Image Note
TS10: primitive streak Present 2A G-/- Authors report normal expression in single mutants.
Specimen 2A N+/-: embryonic day 7.0; Nodaltm1Rob/Nodaltm1Rob (more )
Note: Mid-streak
Structure Level Pattern Image Note
TS10: primitive streak Present 2A N+/- Authors report normal expression in single mutants.
Specimen 2A G-/- N+/- (left): embryonic day 7.0; Gdf1tm1Sjl/Gdf1tm1Sjl, Nodaltm1Rob/Nodal+ (more )
Note: Mid-streak
Structure Level Pattern Image Note
TS10: primitive streak Present 2A G-/- N+/- (left) Expression is differentially dowregulated in double mutant embryos.
Specimen 2A G-/- N+/- (right): embryonic day 7.0; Gdf1tm1Sjl/Gdf1tm1Sjl, Nodaltm1Rob/Nodal+ (more )
Note: Mid-streak
Structure Level Pattern Image Note
TS10: primitive streak Weak Regionally restricted 2A G-/- N+/- (right) Mutant embryos often showed decreased expression in anterior primitive streak.
Specimen 3B WT: embryonic day 9.0 (more )
Structure Level Pattern Image Note
TS14: central nervous system Present 3B WT Expression in the neural tube.
Specimen 3B G-/- N+/-: embryonic day 9.0; Gdf1tm1Sjl/Gdf1tm1Sjl, Nodaltm1Rob/Nodal+ (more )
Structure Level Pattern Image Note
TS14: future brain floor plate Weak 3B G-/- N+/- Expression was significantly dowregulated in floor plate of mutants showing anterior truncation.
Specimen 3C: embryonic day 9.0 (more )
Structure Level Pattern Image Note
TS14: central nervous system Present 3C
Specimen 3D: embryonic day 9.0; Gdf1tm1Sjl/Gdf1tm1Sjl, Nodaltm1Rob/Nodal+ (more )
Structure Level Pattern Image Note
TS14: future brain floor plate Weak 3D Reduced expression in floorplate.
Specimen 4I WT: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: foregut diverticulum endoderm Present 4I WT Expression in foregut endoderm as it forms the foregut diverticulum.
Specimen 4I G-/- N+/- (left): embryonic day 8.5; Gdf1tm1Sjl/Gdf1tm1Sjl, Nodaltm1Rob/Nodal+ (more )
Structure Level Pattern Image Note
TS13: foregut diverticulum endoderm Weak 4I G-/- N+/- (left) Expression dowregulated in foregut endoderm in 50% of mutant embryos examined.
Specimen 4I G-/- N+/- (right): embryonic day 8.5; Gdf1tm1Sjl/Gdf1tm1Sjl, Nodaltm1Rob/Nodal+ (more )
Structure Level Pattern Image Note
TS13: foregut diverticulum endoderm Weak 4I G-/- N+/- (right) Reduced expression in foregut endoderm.
Specimen 7D WT: embryonic day 7.0 (more )
Note: Mid-streak
Structure Level Pattern Image Note
TS10: primitive streak Present Regionally restricted 7D WT Expression in anterior primitive streak.
Specimen 7D G-/-: embryonic day 7.0; Gdf1tm1Sjl/Gdf1tm1Sjl (more )
Note: Mid-streak
Structure Level Pattern Image Note
TS10: primitive streak Present 7D G-/- Single mutants did not show decreased expression.
Specimen 7D 4+/-: embryonic day 7.0; Acvr1btm1Enl/Acvr1b+ (more )
Note: Mid-streak
Structure Level Pattern Image Note
TS10: primitive streak Present 7D 4+/- Single mutants did not show decreased expression.
Specimen 7D 4+/- G-/-: embryonic day 7.0; Acvr1btm1Enl/Acvr1b+, Gdf1tm1Sjl/Gdf1tm1Sjl (more )
Note: Mid-streak
Structure Level Pattern Image Note
TS10: primitive streak Weak Regionally restricted 7D 4+/- G-/- Expression signficantly dowregulated in anterior primitive streak of all double mutants compared to wildtype.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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01/06/2026
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