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Gene Expression Data
Assay Details
Assay
Reference: J:259672 Peng J, et al., Loss of Dcc in the spinal cord is sufficient to cause a deficit in lateralized motor control and the switch to a hopping gait. Dev Dyn. 2018 Apr;247(4):620-629
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6358769
Gene symbol: Robo3
Gene name: roundabout guidance receptor 3
Antibody: Robo3 antibody
Detection system: Alexa Fluor 488
Results
Specimen 2A/A': embryonic day 11.5; Dcctm1Nki/Dcc+, Tg(Hoxb8-cre)1403Uze/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: future spinal cord Present Regionally restricted 2A , 2A' Expression in pre-crossing commissural axons normally forming a fascicle extending towrd the floor plate.
Specimen 2B/B': embryonic day 11.5; Dcctm1Nki/Dcctm1Nki, Tg(Hoxb8-cre)1403Uze/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: future spinal cord Present Regionally restricted 2B , 2B' Pre-crossing commissural axons are defasciculated, fail to turn toward the midline, and instead invade the motor neuron region.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory