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Gene Expression Data
Assay Details
Assay
Reference: J:104160 Tole S, et al., Development of midline cell types and commissural axon tracts requires Fgfr1 in the cerebrum. Dev Biol. 2006 Jan 1;289(1):141-51
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6356600
Gene symbol: Cntn2
Gene name: contactin 2
Antibody: anti-TAG-1 (4D7)
Detection system: fluorescein
Results
Specimen 1B control (left): postnatal day 0; Fgfr1tm1Upir/? (more )
Structure Level Pattern Image Note
TS27: corpus callosum Present Regionally restricted 1B control (left) Expression in callosal axons projecting toward midline.
Specimen 1B control (right): postnatal day 0; Fgfr1tm1Upir/? (more )
Structure Level Pattern Image Note
TS27: corpus callosum Present Regionally restricted 1B control (right) Expression in callosal axons and crossing midline.
Specimen 1B mutant (left): postnatal day 0; Fgfr1tm1Upir/Fgfr1tm1Upir, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: corpus callosum Present Regionally restricted 1B mutant (left) Expression in callosal axons initially projecting normally along intermediate zone of cortical plate, descendking ventrally along midline.
Specimen 1B mutant (right): postnatal day 0; Fgfr1tm1Upir/Fgfr1tm1Upir, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: corpus callosum Present Regionally restricted 1B mutant (right) Expression in callosal axons failing to cross midline, instead forming Probst-like bundles.
Specimen 1D control (left): embryonic day 18.5; Fgfr1tm1Upir/? (more )
Structure Level Pattern Image Note
TS26: anterior commissure Present Regionally restricted 1D control (left) Expression in axons forming the anterior commissure.
Specimen 1D control (middle): embryonic day 18.5; Fgfr1tm1Upir/? (more )
Structure Level Pattern Image Note
TS26: anterior commissure Present Regionally restricted 1D control (middle) Expression in axons forming the anterior commissure.
Specimen 1D control (right): embryonic day 18.5; Fgfr1tm1Upir/? (more )
Structure Level Pattern Image Note
TS26: anterior commissure Present Regionally restricted 1D control (right) Expression in axons crossing the midline.
Specimen 1D mutant (left): embryonic day 18.5; Fgfr1tm1Upir/Fgfr1tm1Upir, Fgfr3tm1Led/Fgfr3+, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: anterior commissure Present Regionally restricted 1D mutant (left) Expression in axons projecting normally along posterior and anterior branches.
Specimen 1D mutant (middle): embryonic day 18.5; Fgfr1tm1Upir/Fgfr1tm1Upir, Fgfr3tm1Led/Fgfr3+, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: anterior commissure Present Regionally restricted 1D mutant (middle) Expression in axons projecting normally along posterior and anterior branches.
Specimen 1D mutant (right): embryonic day 18.5; Fgfr1tm1Upir/Fgfr1tm1Upir, Fgfr3tm1Led/Fgfr3+, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: anterior commissure Present Regionally restricted 1D mutant (right) Expressing axons fail to form a tract crossing the midline.
Specimen 6A: embryonic day 18.5; Foxg1tm1(cre)Skm/Foxg1+ (more )
Structure Level Pattern Image Note
TS26: corpus callosum Present 6A
Specimen 6B: embryonic day 18.5; Foxg1tm1(cre)Skm/Foxg1+ (more )
Structure Level Pattern Image Note
TS26: hippocampal commissure Present 6B
Specimen 6C: embryonic day 18.5; Fgfr1tm1Upir/Fgfr1+, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: corpus callosum Present Regionally restricted 6C Expression in callosal axons turning toward the midline.
Specimen 6D: embryonic day 18.5; Fgfr1tm1Upir/Fgfr1+, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: hippocampal commissure Present Regionally restricted 6D Hippocampal axons accumulating near but not crossing the midline.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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