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Gene Expression Data
Assay Details
Assay
Reference: J:149237 Perez-Balaguer A, et al., Shh dependent and independent maintenance of basal midbrain. Mech Dev. 2009 May-Jun;126(5-6):301-13
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6304447
Gene symbol: Th
Gene name: tyrosine hydroxylase
Antibody: Anti-Th
Results
Specimen 5A: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: midbrain Present Regionally restricted 5A Expression was detected in the dopaminergic cell population.
Specimen 5B: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: midbrain tegmentum Present Regionally restricted 5B Expression was detected in the dopaminergic cells in the ventral tegmental area.
TS26: substantia nigra Present 5B Expression was detected in the dopaminergic cells.
Specimen 5F: embryonic day 12.5; Shhtm2Amc/Shhtm2Amc, En1tm2(cre)Wrst/En1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: midbrain Present Scattered 5F The scattered and disorganized immunopositive cells appeared close to the ventral midline.
Specimen 5G: embryonic day 18.5; Shhtm2Amc/Shhtm2Amc, En1tm2(cre)Wrst/En1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: midbrain Present Regionally restricted 5G Immunopositive cells were located close to the floor plate along the midline.
TS26: midbrain mantle layer Present Scattered 5G Only some immunopositive cells were scattered in the surrounding mantle layer.
TS26: midbrain tegmentum Trace Regionally restricted 5G Almost no positive cells were detected in the presumptive area corresponding to the ventral tegmental area.
Specimen not shown: embryonic day 15.5 (more )
Note: Treated with BrdU.
Structure Level Pattern Image Note
TS23: midbrain Present Proliferating dopaminergic cells were counted.
Specimen not shown: embryonic day 15.5; Shhtm2Amc/Shhtm2Amc, En1tm2(cre)Wrst/En1+ (more )
Note: Conditional mutant. Treated with BrdU.
Structure Level Pattern Image Note
TS23: midbrain Present The number of proliferating dopaminergic cells was dramatically reduced in the conditional mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/21/2024
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