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Gene Expression Data
Assay Details
Assay
Reference: J:55441 Weaver M, et al., Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development. Development. 1999 Sep;126(18):4005-15
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6296569
Gene symbol: Bmp4
Gene name: bone morphogenetic protein 4
Reporter: lacZ
Direct Detection
Results
Specimen 1A: embryonic day 9.0; Bmp4tm2Blh/Bmp4+ (more )
Note: 19 somite-stage embryo.
Structure Level Pattern Image Note
TS14: trunk mesenchyme Present Regionally restricted 1A Expression is in two distinct domains in the ventral mesenchyme surrounding the gut tube and is slighly larger on the right side.

Specimen 1B: embryonic day 9.5; Bmp4tm2Blh/Bmp4+ (more )
Note: 23 somite-stage embryo.
Structure Level Pattern Image Note
TS15: trunk mesenchyme Present Regionally restricted 1B Expression is in the ventral mesenchyme.

Specimen 1C: embryonic day 9.5; Bmp4tm2Blh/Bmp4+ (more )
Note: 27 somite-stage embryo.
Structure Level Pattern Image Note
TS15: lung mesenchyme Present 1C
TS15: trachea Present Regionally restricted 1C Expression is in the mesenchyme.

Specimen 1D: embryonic day 9.5; Bmp4tm2Blh/Bmp4+ (more )
Note: 27 somite-stage embryo.
Structure Level Pattern Image Note
TS15: lung mesenchyme Present 1D
TS15: trachea Present Regionally restricted 1D Expression is in the mesenchyme.

Specimen 1E: embryonic day 10.0; Bmp4tm2Blh/Bmp4+ (more )
Note: 30 somite-stage embryo.
Structure Level Pattern Image Note
TS16: lung mesenchyme Present 1E

Specimen 1F: embryonic day 11.5; Bmp4tm2Blh/Bmp4+ (more )
Structure Level Pattern Image Note
TS19: lung mesenchyme Present 1F
TS19: embryo endoderm Present Regionally restricted 1F Expression is in endodermal tips of the lung and is stronger in the endoderm of the accessory lobe.
TS19: lung Present Regionally restricted 1F Expression is in endodermal tips of the lung and is stronger in the endoderm of the accessory lobe.

Specimen 1G: embryonic day 11.5; Bmp4tm2Blh/Bmp4+ (more )
Structure Level Pattern Image Note
TS19: embryo endoderm Present Regionally restricted 1G Expression is in endodermal tips of the lung.
TS19: lung Present Regionally restricted 1G Expression is in endodermal tips of the lung.

Specimen 1H: embryonic day 14.5; Bmp4tm2Blh/Bmp4+ (more )
Structure Level Pattern Image Note
TS22: endoderm Present Regionally restricted 1H Expression is in endoderm of the distal lung buds.
TS22: lung Present Regionally restricted 1H Expression is in endoderm of the distal lung buds.

Specimen 1I: embryonic day 17.5; Bmp4tm2Blh/Bmp4+ (more )
Structure Level Pattern Image Note
TS25: endoderm Present Regionally restricted 1I Expression is in the highly ramified respiratory endoderm of the lung, particularly in endoderm at the periphery.
TS25: lung Present Regionally restricted 1I Expression is in the highly ramified respiratory endoderm of the lung, particularly in endoderm at the periphery.
TS25: lung mesenchyme Absent 1I

Specimen 2C left: embryonic day 11.5; Bmp4tm2Blh/Bmp4+ (more )
Structure Level Pattern Image Note
TS19: lung mesenchyme Present Regionally restricted 2C left Expression is in the ventral mesenchyme.
TS19: trachea mesenchyme Present Regionally restricted 2C left Expression is in the ventral mesenchyme.

Specimen not shown: embryonic day 13.5; Bmp4tm2Blh/Bmp4+ (more )
Structure Level Pattern Image Note
TS21: lung mesenchyme Absent


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/28/2026
MGI 6.24
The Jackson Laboratory