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Gene Expression Data
Assay Details
Assay
Reference: J:24148 Mitsiadis TA, et al., Midkine (MK), a heparin-binding growth/differentiation factor, is regulated by retinoic acid and epithelial-mesenchymal interactions in the developing mouse tooth, and affects cell proliferation and morphogenesis. J Cell Biol. 1995 Apr;129(1):267-81
Assay type: RNA in situ
MGI Accession ID: MGI:6294282
Gene symbol: Mdk
Gene name: midkine
Probe: pSP65 MK
Probe preparation: Antisense labelled with S35 RNA
Results
Specimen 1a: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: mandibular process mesenchyme Present 1a
TS19: maxillary process mesenchyme Present 1a
TS19: mandibular process Present Regionally restricted 1a Expression is in the epithelium and is downregulated in the basal layer of the dental epithelium.
TS19: maxillary process Present Regionally restricted 1a Expression is in the epithelium and is downregulated in the basal layer of the dental epithelium.
TS19: oral epithelium Present Regionally restricted 1a Expression is in the epithelium and is downregulated in the basal layer of the dental epithelium.
Specimen 1b: embryonic day 13.5 (more )
Note: Bud stage tooth germ.
Structure Level Pattern Image Note
TS21: molar mesenchyme Strong 1b
TS21: lower jaw Present 1b
TS21: mandible Present 1b
TS21: maxilla Present 1b
TS21: upper jaw Present 1b
TS21: molar epithelium Weak 1b
TS21: tooth bud Present Regionally restricted 1b
Specimen 1c: embryonic day 15.5 (more )
Note: Cap stage of tooth development.
Structure Level Pattern Image Note
TS23: molar dental papilla Strong 1c
TS23: mandible Present Regionally restricted 1c Expression is in osteogenic areas.
TS23: molar epithelium Weak 1c
TS23: cap stage tooth Present Regionally restricted 1c
Specimen 1d: embryonic day 16.5 (more )
Note: Early bell stage of tooth development.
Structure Level Pattern Image Note
TS24: dental papilla Strong Regionally restricted 1d Expression is in the mesenchyme surrounding the enamel organ.
TS24: lower jaw molar dental follicle Strong Regionally restricted 1d Expression is in the mesenchyme of the dental follicle surrounding the enamel organ.
TS24: inner enamel epithelium Present Regionally restricted 1d Expression is absent from several cells of the inner dental epithelium.
TS24: early bell stage tooth Present Regionally restricted 1d
Specimen 1e: embryonic day 19.5 (more )
Note: Late bell stage of tooth development.
Structure Level Pattern Image Note
TS26: lower jaw molar dental papilla Present Regionally restricted 1e Expression is in odontoblasts and dental papilla mesenchyme and is upregulated at the tip of the cusps.
TS26: lower jaw molar mesenchyme Present Regionally restricted 1e Expression is in odontoblasts and dental papilla mesenchyme and is upregulated at the tip of the cusps.
TS26: enamel organ Weak Regionally restricted 1e Expression is in preameloblasts.
TS26: stratum intermedium Weak 1e
TS26: late bell stage tooth Present Regionally restricted 1e
Specimen 1f: postnatal day 8 (more )
Structure Level Pattern Image Note
TS28: lower jaw molar dental papilla Present Regionally restricted 1f Expression is in the lower part of the dental papilla mesenchyme and is downregulated in the cusps.
TS28: lower jaw molar enamel organ Absent 1f
Specimen 3a: embryonic day 15.5 (more )
Note: Cap stage of tooth development.
Structure Level Pattern Image Note
TS23: lower jaw molar dental papilla Present 3a
TS23: cap stage tooth Present 3a
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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01/06/2026
MGI 6.24 		The Jackson Laboratory