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Gene Expression Data
Assay Details
Assay
Reference: J:29484 Bennett JH, et al., Bone morphogenetic protein-2 and -4 expression during murine orofacial development. Arch Oral Biol. 1995 Sep;40(9):847-54
Assay type: RNA in situ
MGI Accession ID: MGI:6277150
Gene symbol: Bmp4
Gene name: bone morphogenetic protein 4
Probe: Bmp4 cDNA5
Probe preparation: Antisense labelled with S35 RNA
Visualized with: Autoradiography
Results
Specimen 3A: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: 1st branchial arch maxillary component mesenchyme derived from neural crest Present Diffuse 3A
TS15: 1st branchial arch maxillary component ectoderm Strong Regionally restricted 3A Strong band of expression localized apically in overlying epithelium of maxillary process.

Specimen 3B: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: 1st branchial arch mandibular component mesenchyme derived from neural crest Present Diffuse 3B Diffuse expression in mandibular ectomesenchyme.
TS15: 1st branchial arch mandibular component ectoderm Strong Regionally restricted 3B Strong expression in overlying epithelium on superior and lateral aspects of mandibular process.
TS15: 1st branchial arch mandibular component mesenchyme Trace Regionally restricted 3B Very weak expression (only slightly above background) in underlying mesenchyme.
TS15: heart Strong 3B Strong expression in heart primordia.
TS15: otocyst epithelium Present 3B Expression in epithelial wall of otic vesicle.

Specimen 3C: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: limb ectoderm Present Regionally restricted 3C Expression on apical epithelium of devleoping limb bud.

Specimen 3D: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: 1st branchial arch mandibular component mesenchyme derived from neural crest Weak Diffuse 3D Weak, diffuse expression persists throughout ectomesenchyme of maxillary and mandibular processes.
TS17: 1st branchial arch maxillary component mesenchyme derived from neural crest Weak Diffuse 3D Weak, diffuse expression persists throughout ectomesenchyme of maxillary and mandibular processes.
TS17: 1st branchial arch mandibular component ectoderm Absent 3D No expresssion in epithelium overlying maxiallary and mandibular processes.
TS17: 1st branchial arch maxillary component ectoderm Absent 3D No expresssion in epithelium overlying maxiallary and mandibular processes.
TS17: heart Present 3D Expression persisted in heart primordia.

Specimen E11.5 not shown: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: embryo Weak Authors report expression became less prominenet at E11.5 and successive days.

Specimen 4A/B: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: upper jaw tooth mesenchyme Present Regionally restricted 4A/B Expression in developing maxillary tooth germ. Expression in a very limited group of cells within the dental papilla. Diffuse pattern of expression persists in ectomesenchyme that will form the dental follicle and papilla.
TS21: upper jaw tooth dental lamina Absent 4A/B
TS21: thoracic segment of trunk Present Regionally restricted 4A/B Expression around midline structures of the thorax.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/28/2026
MGI 6.24
The Jackson Laboratory