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Gene Expression Data
Assay Details
Assay
Reference: J:173124 Aujla PK, et al., The Notch effector gene Hes1 regulates migration of hypothalamic neurons, neuropeptide content and axon targeting to the pituitary. Dev Biol. 2011 May 1;353(1):61-71
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6275016
Gene symbol: Avp
Gene name: arginine vasopressin
Results
Specimen 2A: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: hypothalamus Present Regionally restricted 2A At level of the posterior lobe of pituitary, no expression in cell bodies in the region posterior to the supraoptic nucleus.

Specimen 2B: embryonic day 16.5; Hes1tm1Fgu/Hes1tm1Fgu (more )
Structure Level Pattern Image Note
TS24: hypothalamus Present Regionally restricted 2B At level of the posterior lobe, expression in cells in a ventromedial cluster, as well as a few scattered cells laterally.

Specimen 2C: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: hypothalamus Present Regionally restricted 2C At level of the medial median eminence, anterior to the posterior lobe, expression in medial cell bodies in a ventromedial cluster, medial to the supraoptic nucleus.
TS24: supraoptic nucleus Present Regionally restricted 2C Expression in a cluster superior to the optic nerve in the supraoptic nucleus.

Specimen 2D: embryonic day 16.5; Hes1tm1Fgu/Hes1tm1Fgu (more )
Structure Level Pattern Image Note
TS24: median eminence Present Regionally restricted 2D Expression in more dorsal cells at the medial median eminence, anterior to the posterior lobe.
TS24: hypothalamus Present Regionally restricted 2D Expression in scattered cells medial to the supraoptic nucleus.

Specimen 2G: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: median eminence Present Regionally restricted 2G Expression in the paraventricular nucleus, forming a trapezoid pattern at the third ventricle.

Specimen 2I: embryonic day 16.5; Hes1tm1Fgu/Hes1tm1Fgu (more )
Structure Level Pattern Image Note
TS24: paraventricular hypothalamic nucleus Present Diffuse 2I Authors report more diffuse expressing cells in paraventricular nucleus, unrestricted around the third ventricle.

Specimen 3A: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: paraventricular hypothalamic nucleus Strong Regionally restricted 3A Robust expression within the paraventricular nucleus in a distinct pattern on either side of the third ventricle.

Specimen 3B: embryonic day 18.5; Hes1tm1Fgu/Hes1tm1Fgu (more )
Structure Level Pattern Image Note
TS26: paraventricular hypothalamic nucleus Present 3B
TS26: hypothalamus Present Diffuse 3B More diffuse pattern of expression in the superior optic nucleus. Expression in neurons follow border of mesenchyme.

Specimen 3C: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: supraoptic nucleus Present Regionally restricted 3C Expression in tight cluster of neurons superior to the optic nerve,

Specimen 3D: embryonic day 18.5; Hes1tm1Fgu/Hes1tm1Fgu (more )
Structure Level Pattern Image Note
TS26: supraoptic nucleus Present Diffuse 3D More diffuse pattern of expression in the superior optic nucleus. Expression in neurons follow border of mesenchyme.

Specimen 4A: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: neurohypophysis pars nervosa Strong Regionally restricted 4A Robust expression in axon terminals filling posterior lobe.

Specimen 4B: embryonic day 18.5; Hes1tm1Fgu/Hes1tm1Fgu (more )
Structure Level Pattern Image Note
TS26: neurohypophysis pars nervosa Weak Regionally restricted 4B Substantially reduced expression in axons in the hypomorphic posterior lobe.

Specimen 4C: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: median eminence Present Regionally restricted 4C Expression in axons in the median eminence.

Specimen 4D: embryonic day 18.5; Hes1tm1Fgu/Hes1tm1Fgu (more )
Structure Level Pattern Image Note
TS26: median eminence Weak Regionally restricted 4D Decreased expression within the median eminence.
TS26: hypothalamus Present Regionally restricted 4D Expression in an ectopic cluster of cells lateral to the median eminence.

Specimen 5A: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: supraoptic nucleus Present Regionally restricted 5A Expression in the supraoptic nucleus at the level of the anterior lobe in a cluster superior to the optic nerve

Specimen 5B: embryonic day 18.5; Hes1tm1Fgu/Hes1tm1Fgu (more )
Structure Level Pattern Image Note
TS26: median eminence Present Regionally restricted 5B At the level of a smaller anterior lobe, expression in axons traveling through the median eminence
TS26: supraoptic nucleus Present Regionally restricted 5B Expression in a cluster of neurons superior to the optic nerve in the supraoptic nucleus.

Specimen 5C: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: supraoptic nucleus Present Regionally restricted 5C Expression in neurons in the supraoptic nucleus.

Specimen 5D: embryonic day 18.5; Hes1tm1Fgu/Hes1tm1Fgu (more )
Structure Level Pattern Image Note
TS26: median eminence Weak Regionally restricted 5D Decreased expression within the median eminence.
TS26: hypothalamus Present Regionally restricted 5D Expression in an ectopic cluster of cells lateral to the median eminence.

Specimen 5E: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: median eminence Present Regionally restricted 5E At the level of the posterior lobe, expression in axons traveling throught the median eminence to the posterior lobe.
TS26: neurohypophysis pars nervosa Present 5E

Specimen 5F/F': embryonic day 18.5; Hes1tm1Fgu/Hes1tm1Fgu (more )
Structure Level Pattern Image Note
TS26: median eminence Present Regionally restricted 5F , 5F' At the level of the posterior lobe, no expression in axons traveling through the medial eminence.
TS26: supraoptic nucleus Weak Regionally restricted 5F , 5F' Decreased expression within the median eminence.
TS26: hypothalamus Present Regionally restricted 5F , 5F' Expression in an ectopic cluster of cells lateral to the median eminence.


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory