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Gene Expression Data
Assay Details
Assay
Reference: J:229950 Fujita M, et al., Pharyngeal arch artery defects and lethal malformations of the aortic arch and its branches in mice deficient for the Hrt1/Hey1 transcription factor. Mech Dev. 2016 Feb;139:65-73
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6256467
Gene symbol: Jag1
Gene name: jagged 1
Results
Specimen 5Ca: embryonic day 11.5 (more )
Note: Double labeled: green - Jag1; red - Pecam1 (assay MGI:6236304).
Structure Level Pattern Image Note
TS19: 4th arch artery Present Regionally restricted 5Ca , 5Ca' Expression was detected in the 4th pharyngeal arch artery endothelium.
TS19: artery endothelium Present Regionally restricted 5Ca , 5Ca' Expression was detected in the 4th pharyngeal arch artery endothelium.
Specimen 5Cb: embryonic day 11.5; Hey1tm1Ona/Hey1tm1Ona (more )
Note: Structurally intact. Double labeled: green - Jag1; red - Pecam1 (assay MGI:6236304).
Structure Level Pattern Image Note
TS19: 4th arch artery Present Regionally restricted 5Cb , 5Cb' Normal expression was detected in the structurally-intact 4th pharyngeal arch artery endothelium of the mutant.
TS19: artery endothelium Present Regionally restricted 5Cb , 5Cb' Normal expression was detected in the structurally-intact 4th pharyngeal arch artery endothelium of the mutant.
Specimen 5Cc: embryonic day 11.5; Hey1tm1Ona/Hey1tm1Ona (more )
Note: Structurally defective. Double labeled: green - Jag1; red - Pecam1 (assay MGI:6236304).
Structure Level Pattern Image Note
TS19: 4th arch artery Weak Regionally restricted 5Cc' , 5Cc Expression was severely reduced in the structurally-defective 4th pharyngeal arch artery endothelium. This is in contrast to expression of Pecam1, which was unchanged.
TS19: artery endothelium Weak Regionally restricted 5Cc' , 5Cc Expression was severely reduced in the structurally-defective 4th pharyngeal arch artery endothelium. This is in contrast to expression of Pecam1, which was unchanged.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory