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Gene Expression Data
Assay Details
Assay
Reference: J:191199 Mulvaney JF, et al., Secreted Factor R-Spondin 2 is Involved in Refinement of Patterning of the Mammalian Cochlea. Dev Dyn. 2013 Feb;242(2):179-88
Assay type: RNA in situ
MGI Accession ID: MGI:6241476
Gene symbol: Rspo2
Gene name: R-spondin 2
Probe: Rspo2 probe2
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 1A/E/I/M: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: cochlea epithelium Present Regionally restricted 1E , 1A , 1M , 1I Expressed in the basal greater epithelial ridge.

Specimen 1B/F/J/N: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: cochlea epithelium Present Regionally restricted 1N , 1F , 1J , 1B Expression extended from the base to the mid base (around 65% of the length of the cochlea).

Specimen 1C/G/K/O: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: cochlea epithelium Present Regionally restricted 1K , 1O , 1C , 1G Expression had expanded to the apex, was maintained in the mid base, and began to downregulate in the base.

Specimen 1D/H/L/P: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: cochlea epithelium Present Regionally restricted 1L , 1D , 1P , 1H Expression was restricted to the apex and apical portion of the mid base.

Specimen 1Q/R/S/T: embryonic day 17.5 (more )
Note: Double labeled: purple - Rspo2; green - Myo6 (assay MGI:6241481).
Structure Level Pattern Image Note
TS25: cochlea epithelium Present Regionally restricted 1R , 1S , 1T , 1Q Expressed in a region around 75um medial to the organ of Corti in the greater epithelial ridge.

Specimen 1U: embryonic day 17.5 (more )
Note: base area
Structure Level Pattern Image Note
TS25: cochlear duct Present Regionally restricted 1U Expressed in cells of the inner sulcus. Expressed in the luminal surface cells of the most lateral region of the greater epithelial ridge.

Specimen 1V: embryonic day 17.5 (more )
Note: apex area
Structure Level Pattern Image Note
TS25: cochlear duct Present Regionally restricted 1V Expressed in cells of the inner sulcus. In a less mature region of the cochlea, expression spaned the depth of the greater epithelial ridge and was more diffuse.

Specimen not shown: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: cochlea Absent


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory