About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:204375 Sheth R, et al., "Self-regulation," a new facet of Hox genes' function. Dev Dyn. 2014 Jan;243(1):182-91
Assay type: RNA in situ
MGI Accession ID: MGI:6241386
Gene symbol: Hoxd4
Gene name: homeobox D4
Probe: Hoxd4 probe14
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 1A: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: limb Present Regionally restricted 1A Expression was detected in a small central domain.
Specimen 1B: embryonic day 11.5; Del(2Hoxd11-Hoxd13)29Ddu/Del(2Hoxd11-Hoxd13)29Ddu (more )
Structure Level Pattern Image Note
TS19: limb Present Regionally restricted 1B The expression domain was slightly extended into the posterior limb mesenchyme in the mutant.
TS19: limb mesenchyme Present Regionally restricted 1B The expression domain was slightly extended into the posterior limb mesenchyme in the mutant.
Specimen 2A: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: limb Present Regionally restricted 2A Expression was detected in a small central domain.
Specimen 2B: embryonic day 11.5; Hoxa13tm1Ipc/Hoxa13tm1Ipc (more )
Structure Level Pattern Image Note
TS19: limb Present Regionally restricted 2B Expression was upregulated and distally expanded in the anterior and posterior mesenchyme of the Hoxa13 mutant.
TS19: limb mesenchyme Present Regionally restricted 2B Expression was upregulated and distally expanded in the anterior and posterior mesenchyme of the Hoxa13 mutant.
Specimen 2C: embryonic day 11.5; Del(2Hoxd11-Hoxd13)29Ddu/+, Hoxa13tm1Ipc/Hoxa13tm1Ipc (more )
Structure Level Pattern Image Note
TS19: limb Present Regionally restricted 2C Similar to the expression in Fig. 2B, ectopic expression was observed in the double mutant.
TS19: limb mesenchyme Present Regionally restricted 2C Similar to the expression in Fig. 2B, ectopic expression was observed in the double mutant.
Specimen 5A: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: forelimb bud Present Regionally restricted 5A Expression was detected in a small central domain.
Structure Level Pattern Image Note
TS19: forelimb bud mesenchyme Present Regionally restricted 5B Ectopic expression was detected in the distal mesenchyme.
Specimen 5I: embryonic day 11.5; Hoxa13tm1Ipc/Hoxa13tm1Ipc, Hoxdtm11Ddu/Hoxdtm11Ddu (more )
Structure Level Pattern Image Note
TS19: forelimb bud Present Regionally restricted 5I Expression was extended distally and covers the entire distal limb bud.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory