Gene Expression Data
Assay Details
|
Assay
|
|
Reference:
|
J:141989
Kirjavainen A, et al., Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia. Dev Biol. 2008 Oct 1;322(1):33-45
|
|
Assay type:
|
In situ reporter (knock in)
|
|
MGI Accession ID:
|
MGI:6195822
|
|
Gene symbol:
|
Gfi1
|
|
Gene name:
|
growth factor independent 1 transcription repressor
|
|
|
Results
|
Specimen
8C:
postnatal day 0; Gfi1tm2Tmo/Gfi1 +
(more  )
Specimen
8C:
(close  )
|
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ
|
|
Mutant Allele(s):
|
Gfi1tm2Tmo/Gfi1+
|
|
Age:
|
postnatal day 0
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS27: cochlea |
Present |
Regionally restricted |
8C
|
Authors report expression in 4 rows of hair cells.
|
Specimen
8D:
(close )
|
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ
|
|
Mutant Allele(s):
|
Gfi1tm2Tmo/Gfi1tm2Tmo
|
|
Age:
|
embryonic day 17.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS25: cochlea |
Present |
Regionally restricted |
8D
|
Expression in intact hair cells. Authors report outer hair cells were present but showed abnormal morphology and were not arranged as distinct rows.
|
Specimen
8E:
(close )
|
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ
|
|
Mutant Allele(s):
|
Gfi1tm2Tmo/Gfi1tm2Tmo
|
|
Age:
|
postnatal day 0
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS27: cochlea |
Present |
Regionally restricted |
8E
|
Authors report prominent degeneration and loss of hair cells. Most of outer hair cells were severely pathological or lost.
|
|
Analysis Tools
