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Gene Expression Data
Assay Details
Assay
Reference: J:122606 Cheng LE, et al., The transcription factor Zfp423/OAZ is required for cerebellar development and CNS midline patterning. Dev Biol. 2007 Jul 1;307(1):43-52
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6162055
Gene symbol: Zfp423
Gene name: zinc finger protein 423
Reporter: lacZ
Direct Detection
Results
Specimen 1b: embryonic day 8.5; Zfp423Gt(XB409)Byg/Zfp423+ (more )
Structure Level Pattern Image Note
TS13: neural tube Present Regionally restricted 1b Bilateral expression along dorsal neural tube.

Specimen 1c: embryonic day 9.5; Zfp423Gt(XB409)Byg/Zfp423+ (more )
Structure Level Pattern Image Note
TS15: central nervous system Present Regionally restricted 1c Two narrow continuous bands of expression along the dorsal midline extending from telencephalon caudally along entire body axis.
TS15: future forebrain Strong 1c Most intense expresssion in forebrain, hindbrain and rostral spinal cord.

Specimen 1d: embryonic day 9.5; Zfp423Gt(XB409)Byg/Zfp423+ (more )
Structure Level Pattern Image Note
TS15: future hindbrain Strong 1d Most intense expresssion in forebrain, hindbrain and rostral spinal cord.
TS15: future spinal cord Strong Regionally restricted 1d Most intense expresssion in forebrain, hindbrain and rostral spinal cord.

Specimen 1e: embryonic day 9.5; Zfp423Gt(XB409)Byg/Zfp423+ (more )
Structure Level Pattern Image Note
TS15: neural ectoderm Present 1e Expression mainly detected in neuroepithelium.

Specimen 1f: embryonic day 9.5; Zfp423Gt(XB409)Byg/Zfp423+ (more )
Structure Level Pattern Image Note
TS15: neural tube Strong Regionally restricted 1f Expression stronger in dorsal neuroepithelium flanking the roof plate.
TS15: future forebrain Present 1f

Specimen 1g: embryonic day 9.5; Zfp423Gt(XB409)Byg/Zfp423+ (more )
Structure Level Pattern Image Note
TS15: future hindbrain Present 1g

Specimen 1h: embryonic day 14.5; Zfp423Gt(XB409)Byg/Zfp423+ (more )
Structure Level Pattern Image Note
TS22: cerebellum Present 1h
TS22: midbrain ventricular layer Present 1h
TS22: olfactory epithelium Present 1h
TS22: telencephalon septum Present 1h
TS22: cerebral cortex ventricular layer Weak 1h

Specimen 1i: embryonic day 15.5; Zfp423Gt(XB409)Byg/Zfp423+ (more )
Structure Level Pattern Image Note
TS23: cerebellum layer Present Regionally restricted 1i Expression in Purkinje cell layer and external granule cell layer.
TS23: cerebellum external granule cell layer Present 1i

Specimen 1j: postnatal day 0; Zfp423Gt(XB409)Byg/Zfp423+ (more )
Structure Level Pattern Image Note
TS27: cerebellum Purkinje cell layer Weak 1j Expression in both Purkinje cell layer and external granule cell layer decreases postnatally.
TS27: cerebellum external granule cell layer Weak 1j Expression in both Purkinje cell layer and external granule cell layer decreases postnatally.
TS27: cerebellum anterior lobe Present 1j Higher levels of expression in rostral lobes than in caudal lobes.

Specimen 1k: postnatal day 6; Zfp423Gt(XB409)Byg/Zfp423+ (more )
Structure Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Weak 1k Expression in both Purkinje cell layer and external granule cell layer decreases postnatally.
TS28: cerebellum external granule cell layer Weak 1k Expression in both Purkinje cell layer and external granule cell layer decreases postnatally.
TS28: cerebellum anterior lobe Present 1k Higher levels of expression in rostral lobes than in caudal lobes.

Specimen not shown: postnatal adult; Zfp423Gt(XB409)Byg/Zfp423+ (more )
Structure Level Pattern Image Note
TS28: cerebellum Absent

Specimen 2b: embryonic day 15.5; Zfp423Gt(XB409)Byg/Zfp423+ (more )
Structure Level Pattern Image Note
TS23: telencephalon septum Present 2b

Specimen 2c: embryonic day 15.5; Zfp423Gt(XB409)Byg/Zfp423Gt(XB409)Byg (more )
Structure Level Pattern Image Note
TS23: telencephalon septum Present 2c Authors report septum is reduced, and lateral ventricles are enlarged.

Specimen 2e: embryonic day 15.5; Zfp423Gt(XB409)Byg/Zfp423+ (more )
Structure Level Pattern Image Note
TS23: thalamus Present 2e

Specimen 2f: embryonic day 15.5; Zfp423Gt(XB409)Byg/Zfp423Gt(XB409)Byg (more )
Structure Level Pattern Image Note
TS23: thalamus Present 2f Authors report lateral ventricles are enlarged.

Specimen 2h: embryonic day 15.5; Zfp423Gt(XB409)Byg/Zfp423+ (more )
Structure Level Pattern Image Note
TS23: cerebellum Present 2h

Specimen 2i: embryonic day 15.5; Zfp423Gt(XB409)Byg/Zfp423Gt(XB409)Byg (more )
Structure Level Pattern Image Note
TS23: cerebellum Present Regionally restricted 2i Authors report cerebellar plate and medulla oblongata are considerably smaller, and 4th ventricle is enlarged.
TS23: medulla oblongata Present Regionally restricted 2i Authors report cerebellar plate and medulla oblongata are considerably smaller, and 4th ventricle is enlarged.


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory