Gene Expression Data
Assay Details
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Assay
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Reference:
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J:104555
Viviano BL, et al., Altered hematopoiesis in glypican-3-deficient mice results in decreased osteoclast differentiation and a delay in endochondral ossification. Dev Biol. 2005 Jun 1;282(1):152-62
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Assay type:
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RNA in situ
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MGI Accession ID:
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MGI:6153847
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Gene symbol:
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Acp5
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Gene name:
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acid phosphatase 5, tartrate resistant
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Probe:
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TRAP probe1
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Probe preparation:
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Antisense labelled with S35 RNA
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Visualized with:
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Autoradiography
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Results
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Specimen
6B:
embryonic day 16.5
(more  )
Specimen
6B:
(close  )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 16.5
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Sex:
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Male
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS24: tibia |
Present |
Regionally restricted |
6B
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Authors report normal pattern of expression in osteoclasts adjacent to developing bone, as well as invasion of the diaphysis by osteoclasts.
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Specimen
6D:
embryonic day 16.5; Gpc3tm1Snd/Y
(more )
Specimen
6D:
(close )
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Genetic Background:
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involves: 129X1/SvJ * C57BL/6
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Mutant Allele(s):
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Gpc3tm1Snd/Y
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Age:
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embryonic day 16.5
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Sex:
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Male
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS24: tibia |
Present |
Regionally restricted |
6D
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Authors report a dramatic reduction in osteoclast numbers localized to bones, as well as signification fewer cells invaded within the apoptic region of the hypertrophic zone.
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Analysis Tools
