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Gene Expression Data
Assay Details
Assay
Reference: J:54600 Zhang Y, et al., Msx1 is required for the induction of Patched by Sonic hedgehog in the mammalian tooth germ. Dev Dyn. 1999 May;215(1):45-53
Assay type: RNA in situ
MGI Accession ID: MGI:6120863
Gene symbol: Ptch1
Gene name: patched 1
Probe: Ptc1 probe1
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 2B: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: 1st branchial arch mandibular component Present Regionally restricted 2B Expression in incisor and molar forming regions.
TS18: tongue Present 2B
Specimen 2E: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: dental placode Present Regionally restricted 2E Expression in incisor and molar regions.
TS19: mandible primordium Present Regionally restricted 2E Expression in incisor and molar regions.
TS19: tongue Present 2E
Specimen 2H: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: jaw primordium epithelium Weak Regionally restricted 2H Relatively weak expression in dental epithelium.
TS19: jaw primordium mesenchyme Strong Regionally restricted 2H Strong expression in dental mesenchyme.
Specimen 2K: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: dental placode Present Regionally restricted 2K Expression in incisor and molar regions.
TS20: mandible primordium Present Regionally restricted 2K Expression in incisor and molar regions.
TS20: tongue Present 2K
Specimen 3H: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: lower jaw molar epithelium Weak 3H Relatively weak expression in dental epithelium.
TS21: lower jaw molar mesenchyme Strong 3H Strong expression in dental mesenchyme.
Specimen 3A: embryonic day 11.5; Msx1tm1Rilm/Msx1tm1Rilm (more )
Structure Level Pattern Image Note
TS19: dental placode Weak Regionally restricted 3A Weak expression in incisor and molar tooth germ.
TS19: mandible primordium Weak Regionally restricted 3A Weak expression in incisor and molar tooth germ.
Specimen 3A inset: embryonic day 11.5; Msx1tm1Rilm/Msx1tm1Rilm (more )
Structure Level Pattern Image Note
TS19: jaw primordium epithelium Present Regionally restricted 3A inset Expression in dental epithelium.
TS19: jaw primordium mesenchyme Weak Regionally restricted 3A inset Expression downregulated in dental mesenchyme.
Specimen 3D: embryonic day 12.5; Msx1tm1Rilm/Msx1tm1Rilm (more )
Structure Level Pattern Image Note
TS20: dental placode Trace Regionally restricted 3D Expression almost undetectable in dental mesenchyme.
TS20: mandible primordium Trace Regionally restricted 3D Expression almost undetectable in dental mesenchyme.
TS20: tongue Present 3D Expression not affected in mutant tongue.
Specimen 3G: embryonic day 13.5; Msx1tm1Rilm/Msx1tm1Rilm (more )
Structure Level Pattern Image Note
TS21: lower jaw molar epithelium Weak 3G Weak expression in dental epithelium.
TS21: lower jaw molar mesenchyme Absent 3G Expression undetectable in dental mesenchyme.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory