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Gene Expression Data
Assay Details
Assay
Reference: J:257228 Li S, et al., Differential expression of transforming growth factor-beta1, connective tissue growth factor, phosphorylated-SMAD2/3 and phosphorylated-ERK1/2 during mouse tooth development. J Mol Histol. 2017 Dec;48(5-6):347-355
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6120498
Gene symbol: Smad2
Gene name: SMAD family member 2
Antibody: p-SMAD2/3 antibody
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
Results
Specimen 2A: embryonic day 13.5 (more )
Note: Bud stage.
Structure Level Pattern Image Note
TS21: tooth bud Present Regionally restricted 2A
TS21: oral epithelium Strong 2A
TS21: tooth epithelium Strong Regionally restricted 2A Authors report strong expression on internal side of tooth bud.
TS21: tooth mesenchyme Weak 2A
Specimen 2B: embryonic day 14.5 (more )
Note: Cap stage.
Structure Level Pattern Image Note
TS22: cap stage tooth Present Regionally restricted 2B
TS22: inner enamel epithelium Weak 2B
TS22: outer enamel epithelium Weak 2B
TS22: stellate reticulum Weak 2B
TS22: cervical loop Absent 2B
TS22: primary enamel knot Absent 2B
TS22: dental papilla Absent 2B
Specimen 2C: embryonic day 16.5 (more )
Note: Bell stage.
Structure Level Pattern Image Note
TS24: bell stage tooth Present Regionally restricted 2C
TS24: cervical loop Strong 2C
TS24: stellate reticulum Weak 2C
TS24: inner enamel epithelium Absent 2C
TS24: outer enamel epithelium Absent 2C
TS24: secondary enamel knot Absent 2C
TS24: stratum intermedium Absent 2C
TS24: dental papilla Absent 2C
Specimen 2D: postnatal day 0.5 (more )
Note: Presecretory stage.
Structure Level Pattern Image Note
TS27: tooth Present Regionally restricted 2D
Specimen 2E: postnatal day 0.5 (more )
Note: Presecretory stage.
Structure Level Pattern Image Note
TS27: outer enamel epithelium Strong 2E Strong expression in outer enamel epithelium and stellate reticulum.
TS27: stellate reticulum Strong 2E Strong expression in outer enamel epithelium and stellate reticulum.
Specimen 2F: postnatal day 0.5 (more )
Note: Presecretory stage.
Structure Level Pattern Image Note
TS27: stratum intermedium Present Regionally restricted 2F
TS27: enamel organ Weak Regionally restricted 2F Sparce expression in preameloblasts.
TS27: dental pulp Strong 2F
TS27: dental papilla Absent 2F
Specimen 2G: postnatal day 3.5 (more )
Note: Secretory stage.
Structure Level Pattern Image Note
TS27: tooth Present Regionally restricted 2G
Specimen 2H: postnatal day 3.5 (more )
Note: Secretory stage.
Structure Level Pattern Image Note
TS27: stratum intermedium Strong 2H
TS27: outer enamel epithelium Weak 2H
TS27: stellate reticulum Weak 2H
Specimen 2I: postnatal day 3.5 (more )
Note: Secretory stage.
Structure Level Pattern Image Note
TS27: dental pulp Strong 2I
TS27: enamel organ Strong 2I
TS27: dental papilla Absent 2I No expression in odontoblasts.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory