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Gene Expression Data
Assay Details
Assay
Reference: J:78982 Shavit JA, et al., Impaired megakaryopoiesis and behavioral defects in mafG-null mutant mice. Genes Dev. 1998 Jul 15;12(14):2164-74
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:5908690
Gene symbol: Mafg
Gene name: v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)
Reporter: lacZ
Direct Detection
Assay notes: Specimens fixed with 1% formaldehyde, 0.2% glutaraldehyde.
Results
Specimen 2a: postnatal adult; Mafgtm1Jeng/Mafg+ (more )
Structure Level Pattern Image Note
TS28: spleen Present Regionally restricted 2a Expression in megakaryocytes.
Specimen 2b: postnatal adult; Mafgtm1Jeng/Mafgtm1Jeng (more )
Structure Level Pattern Image Note
TS28: spleen Present Regionally restricted 2b Expansion of megakaryocyte population; authors report a threefold increase in megakaryocytes in comparison with heterozygous littermates.
Specimen 4a: embryonic day 6.5; Mafgtm1Jeng/Mafgtm1Jeng (more )
Structure Level Pattern Image Note
TS9: embryo ectoderm Strong 4a
TS9: embryo mesoderm Strong 4a
TS9: extraembryonic component Trace 4a Very weak expression in extraembryonic tissues.
Specimen E7.5 not shown: embryonic day 7.5; Mafgtm1Jeng/Mafgtm1Jeng (more )
Structure Level Pattern Image Note
TS11: embryo Present Widespread Expression throughout most of embryo.
Specimen 4c: embryonic day 8.5; Mafgtm1Jeng/Mafgtm1Jeng (more )
Structure Level Pattern Image Note
TS13: embryo Present Widespread 4c Authors report continued strong embryonic expression throughout entire embryo.
TS13: neural tube Very strong 4c Especially intense expression in neural tube.
TS13: ectoplacental cone Strong 4c Expression intensifies in ectoplacental cone.
TS13: extraembryonic component Weak 4c
Specimen 4e: embryonic day 9.5; Mafgtm1Jeng/Mafgtm1Jeng (more )
Structure Level Pattern Image Note
TS15: embryo Present Widespread 4e Expression throughout almost entire embryo.
TS15: yolk sac mesenchyme Weak Regionally restricted 4e Weak expression in yolk sac blood islands first detectable.
Specimen 4g: embryonic day 12.5; Mafgtm1Jeng/Mafgtm1Jeng (more )
Structure Level Pattern Image Note
TS20: embryo Present Widespread 4g Expression throughout almost entire embryo.
TS20: liver Strong Regionally restricted 4g Strong expression in hematopoietic compartment of fetal liver.
Specimen 4i: embryonic day 14.5; Mafgtm1Jeng/Mafgtm1Jeng (more )
Structure Level Pattern Image Note
TS22: lens Strong 4i
TS22: retina Strong 4i
Specimen E14.5 not shown: embryonic day 14.5; Mafgtm1Jeng/Mafgtm1Jeng (more )
Structure Level Pattern Image Note
TS22: embryo Present Widespread Expression throughout almost entire embryo.
TS22: brain Strong
TS22: cranial nerve Strong
TS22: dorsal root ganglion Strong
TS22: intestine epithelium Strong
TS22: skeletal muscle Strong
Specimen postnatal not shown: postnatal; Mafgtm1Jeng/Mafgtm1Jeng (more )
Structure Level Pattern Image Note
TS28: epidermis Strong
TS28: gut epithelium Strong
TS28: hair follicle Strong
TS28: renal tubule Strong
TS28: respiratory tract epithelium Strong
Specimen 5a: embryonic day 12.5; Mafgtm1Jeng/Mafgtm1Jeng (more )
Structure Level Pattern Image Note
TS20: liver Strong Regionally restricted 5a Strong expression in differentiating megakaryocytes of fetal liver.
Specimen newborn not shown: postnatal newborn; Mafgtm1Jeng/Mafgtm1Jeng (more )
Structure Level Pattern Image Note
TS27: liver Present Regionally restricted Expression in megakaryocytes.
Specimen 5c: postnatal adult; Mafgtm1Jeng/Mafgtm1Jeng (more )
Structure Level Pattern Image Note
TS28: bone marrow Strong Regionally restricted 5c Intense expression in adult mutant megakaryocytes.
Specimen 6a: postnatal newborn; Mafgtm1Jeng/Mafgtm1Jeng (more )
Structure Level Pattern Image Note
TS27: saccule epithelium Present 6a
TS27: vestibulo-cochlear ganglion Present 6a
Specimen 6b: postnatal adult; Mafgtm1Jeng/Mafgtm1Jeng (more )
Structure Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Strong 6b
TS28: cerebellum granule cell layer Strong 6b
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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