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Gene Expression Data
Assay Details
Assay
Reference: J:98688 Tang LS, et al., Dynamic expression of COUP-TFI and COUP-TFII during development and functional maturation of the mouse inner ear. Gene Expr Patterns. 2005 Jun;5(5):587-92
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5907893
Gene symbol: Nr2f1
Gene name: nuclear receptor subfamily 2, group F, member 1
Antibody: COUP-TFI antibody
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 2F: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: cochlear duct Strong Regionally restricted 2F Protein highly expressed and localized in nuclei of cells.
Specimen 2G: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: greater epithelial ridge Strong 2G Strong expression in greater epithelial ridge; Higher expression in inner sulcus cells of greater epithelial ridge.
TS23: lesser epithelial ridge Weak 2G Clear demarcation at border with lesser epithelium ridge at the apical coil.
Specimen 2H: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: cochlear duct epithelium Present Regionally restricted 2H
Specimen 2I: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: cochlear duct epithelium Weak Regionally restricted 2I s development proceeds in apical to basal direction, relative expression level decreases in sensory epithelium.
Specimen 2J: embryonic day 15.5; Nr2f1tm1Mjts/Nr2f1tm1Mjts (more )
Structure Level Pattern Image Note
TS23: cochlear duct epithelium Absent 2J
Specimen 3A: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: organ of Corti Present Regionally restricted 3A Expression in organ of Corti at all turns of cochlear duct.
Specimen 3B: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: organ of Corti Present Regionally restricted 3B Expression in a single row of inner hair cells, the first three rows of outer hair cells, and Hensen's cells. Fairly equal distribution in nuclei and cytoplasm of hair cells.
TS27: basilar membrane Present 3B
TS27: internal spiral sulcus Present 3B
TS27: vestibular membrane Present Regionally restricted 3B Expression in Reissner's membrane limited to squamous mesothelial cells facing the scala vestibuli.
Specimen 3C: postnatal day 4 (more )
Structure Level Pattern Image Note
TS28: organ of Corti Weak Regionally restricted 3C Gradually diminishing expression in maturing hair cells. Expression in nuclei of Hensen's cell and Deiter's cells.
TS28: basilar membrane Present 3C
TS28: internal spiral sulcus Present 3C
TS28: vestibular membrane Present Regionally restricted 3C Expression in mesothelial cells of Reissner's membrane.
Specimen P6 not shown: postnatal day 6 (more )
Structure Level Pattern Image Note
TS28: organ of Corti Present Regionally restricted Expression in inner and outer pillar cells.
Specimen 3D: postnatal day 25 (more )
Structure Level Pattern Image Note
TS28: organ of Corti Present Regionally restricted 3D Expression localized to cytoplasm and nuclei of both inner and outer pillar cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/21/2024
MGI 6.23 		The Jackson Laboratory